Indications |
Oral Muscle spasms Adult: As citrate: 100 mg bid orally. Oral Parkinsonism and drug-induced extrapyramidal syndrome Adult: As hydrochloride: Initially, 150 mg daily in divided doses; increase gradually by 50 mg every 2-3 days depending on response. Maintenance: 150-300 mg/day. Some patients may require up to 400 mg daily. Max Dosage: 400 mg/day. Parenteral Muscle spasms Adult: As citrate: 60 mg every 12 hr by IM or slow IV (over 5 min) inj. |
Contraindications |
Glaucoma, prostatic hypertrophy, GI obstruction, stenosing peptic ulcer, bladder neck obstruction, cardiospasm, myasthenia gravis. |
Warnings / Precautions |
Elderly; pregnancy and lactation. May impair ability to drive or operate machinery. CHF, cardiac decompensation, coronary insufficiency , tachycardia, or cardiac arrhythmias. History of drug abuse or acute alcoholism. |
Adverse Reactions |
Palpitation, tachycardia; agitation, drowsiness, dizziness, euphoria, hallucination, headache, mental confusion; pruritus, urticaria; constipation, gastric irritation, nausea, vomiting, xerostomia; urination hesitancy, urinary retention; aplastic anaemia (rare); tremor, weakness; blurred vision, increased intraocular pressure, nystagmus, pupil dilatation; nasal congestion; hypersensitivity. Potentially Fatal: Anaphylactic reactions (rare). |
Overdose Reactions |
Symptoms: Blurred vision, tachycardia, confusion, seizures, respiratory arrest, dysrhythmias. 2-3 g may be lethal in adults. Management: Physostigmine 1-2 mg IV slowly may be given to reverse anticholinergic effects. Otherwise, treatment is symptomatic and supportive. |
Drug Interactions |
Reduced effect with acetylcholinesterase inhibitors e.g. donepezil, galantamine, rivastigmine, tacrine; may reduce effect of centrally-acting acetylcholinesterase inhibitors. Additive sedative effects with CNS depressants, alcohol. Pramlintide may increase anticholinergic effect on the GI tract. Increased risk of anticholinergic adverse effects with diphenhydramine, TCAs, phenothiazines. See Below for More orphenadrine Drug Interactions |
Food Interactions |
Additive CNS depression may occur with valerian, St John's wort, kava kava, gotu kola. |
Mechanism of Actions |
Orphenadrine is a tertiary amine antimuscarinic which exerts antiparkinsonian action by inhibiting excess central cholinergic effects that occur due to dopamine deficiency. It reduces muscle spasms possibly by its atropine-like effect on the medulla or on cerebral motor centers. Absorption: Readily absorbed from the GI tract and after IM inj. Metabolism: Almost completely metabolised to at least 8 metabolites. Excretion: Mainly via urine (as metabolites and traces of unchanged drug). Half-life: 14 hr. |
Administration |
May be taken with or without food. (May be taken w/ meals if GI upset occurs.) |
Storage Conditions |
Oral: Store at 15-30°C (59-86°F). Parenteral: Store at 15-30°C (59-86°F). Protect from light. |
Storage |
Oral: Store at 15-30°C (59-86°F). Parenteral: Store at 15-30°C (59-86°F). Protect from light. |
Available As |
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Orphenadrine
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Orphenadrine Containing Brands
Orphenadrine is used in following diseases
Drug - Drug Interactions of Orphenadrine
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