Nicergoline

Indications
 Oral
Peripheral vascular disease
Adult: 10 mg tid. Maintenance: 5-10 mg tid. Max: Up to 60 mg daily in divided doses.
Renal impairment: Reduce dose.
Oral
Mental deterioration associated with cerebrovascular insufficiency
Adult: 10 mg tid. Maintenance: 5-10 mg tid. Max: Up to 60 mg daily in divided doses.
Renal impairment: Reduce dose.
Intramuscular
Peripheral vascular disease
Adult: 2-4 mg bid.
Renal impairment: Reduce dose.
Intramuscular
Symptoms of mental deterioration associated with cerebrovascular insufficiency
Adult: 2-4 mg bid.
Renal impairment: Reduce dose.
Intravenous
Peripheral vascular disease
Adult: 4-8 mg by slow IV infusion (over 30 min).
Renal impairment: Reduce dose.
Intravenous
Symptoms of mental deterioration associated with cerebrovascular insufficiency
Adult: 4-8 mg by slow IV infusion (over 30 min).
Renal impairment: Reduce dose.

Reconstitution: Dilute in 250 ml saline solution.
Warnings / Precautions
 Porphyria. Pregnancy.
Adverse Reactions
 GI disturbances; hypotension (especially after parenteral admin). Hot flushes, malaise, hyperacidity, nausea, diarrhoea, dizziness, somnolence.
Drug Interactions
 May potentiate action of antihypertensives. May increase cardiac depressant effects of propranolol.
See Below for More nicergoline Drug Interactions
Mechanism of Actions
 Nicergoline is an ergot derivative. It has α-adrenergic blocking activity and produces vasodilatation.
Onset: 1-1.5 hr (oral).
Absorption: Rapidly absorbed from the GI tract (oral).
Distribution: Protein-binding: 82-87%.
Metabolism: Undergoes significant 1st-pass effect.
Excretion: Via urine (80%), via faeces (20%).
Administration
 Should be taken on an empty stomach. (Take on an empty stomach.)
ATC Classification
 C04AE02 - nicergoline ; Belongs to the class of ergot alkaloids. Used as peripheral vasodilators.
Available As
  • Nicergoline 30 mg
  • Nicergoline 5 mg

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