Nevirapine

Indications
 Oral
HIV infection
Adult: Combined with other antiretrovirals: 200 mg once daily for the first 14 days; increase to 200 mg bid if rash does not develop. Interrupting the treatment for >7 days necessitate reintroduction at a lower dose for the first 14 days.
Child: Combined with other antiretrovirals: 2 mth to 8 yr: 4 mg/kg once daily for the first 14 days; increase to 7 mg/kg bid if no rash is present. 8-16 yr: 4 mg/kg once daily for 14 days followed by 4 mg/kg bid. Max: 400 mg daily. Interrupting the treatment for >7 days necessitate reintroduction at a lower dose for the first 14 days.
Renal impairment: Haemodialysis: A further 200-mg dose is recommended after dialysis.
Contraindications
 Hypersensitivity. Lactation. Severe hepatic impairment.
Warnings / Precautions
 Pregnancy. Interrupt treatment if severe hepatotoxicity or life-threatening skin reactions develop. Renal or hepatic insufficiency. Monitor liver function periodically.
Adverse Reactions
 Skin rash, nausea, vomiting, headache, abnormal LFT, fatigue, diarrhoea, abdominal pain.
Potentially Fatal: Severe and life-threatening hepatotoxic and skin reactions.
Overdose Reactions
 Symptoms: Oedema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonary infiltrates, rash, vertigo, wt loss. Management: No known antidote.
Drug Interactions
 Mutually increased levels effects when used with drugs extensively metabolised by CYP3A. Reduced levels/effects of methadone.
See Below for More nevirapine Drug Interactions
Food Interactions
 Reduced serum levels with St John's wort.
Mechanism of Actions
 Nevirapine is a non-nucleoside reverse transcriptase inhibitor that acts against HIV-1. It binds directly to reverse transcriptase and thereby blocks the RNA-dependent and DNA-dependent DNA polymerase activities by disrupting the enzyme's catalytic site.
Absorption: Readily absorbed from the GI tract; peak plasma concentrations after 4 hr (oral).
Distribution: Crosses the placenta; enters breast milk. Protein-binding: Approx 60%.
Metabolism: Hepatic by microsomal enzymes.
Excretion: Via urine (as glucuronide conjugates of the hydroxylated metabolites).
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 15-30°C (59-86°F).
ATC Classification
 J05AG01 - nevirapine ; Belongs to the class of non-nucleoside reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Storage
 Oral: Store at 15-30°C (59-86°F).
Available As
  • Nevirapine 10 mg
  • Nevirapine 100 mg
  • Nevirapine 200 mg
  • Nevirapine 50 mg
  • Nevirapine 70 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Nevirapine


    Nevirapine Containing Brands

    We are Developing Our database, More results coming soon.

    Nevirapine is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Nevirapine

    We are Developing Our database, More results coming soon.