Methdilazine

Indications
 Oral
Pruritic skin disorders, Hypersensitivity reactions
Adult: 8-16 mg bid.
Child: 3-6 yr: 0.3 mg/kg/day, max 8 mg/day. 6-12 yr: 4 mg bid.
Contraindications
 Neonates; narrow-angle glaucoma; GI tract/urinary outflow obstruction, paralytic ileus.
Warnings / Precautions
 Elderly; caution in driving; peptic ulcer; epilepsy; severe CV disease, benign prostatic hyperplasia; pregnancy and lactation; asthma, bronchitis; hepatic or renal impairment; Parkinson's disease.
Adverse Reactions
 Drowsiness, CNS depression, paradoxical excitation (children). Dry mouth, blurring of vision; constipation, retention of urine; bradycardia followed by tachycardia and arrhythmias. GI disturbances; blood dyscrasias; giddiness; hypotension; headache; asthma; tremors; photosensitivity; jaundice; menstrual disorders.
Drug Interactions
 Potentiates CNS depressant action of alcohol, barbiturates, hypnotics, opioid analgesics, sedatives and neuroleptics. Antimuscarinic effects potentiated by MAOIs, atropine and TCAs. May reduce effect of levodopa.
See Below for More methdilazine Drug Interactions
Food Interactions
 None reported.
Mechanism of Actions
 Methdilazine, a phenothiazine derivative, is a sedating antihistamine with antimuscarinic and possibly some serotonin-antagonist properties.
Administration
 May be taken with or without food.
ATC Classification
 R06AD04 - methdilazine ; Belongs to the class of phenothiazine derivatives used as systemic antihistamines.
Available As
  • Methdilazine 2.5 mg
  • Methdilazine 4 mg
  • Methdilazine 8 mg

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