Pruritic skin disorders, Hypersensitivity reactions
Adult: 8-16 mg bid.
Child: 3-6 yr: 0.3 mg/kg/day, max 8 mg/day. 6-12 yr: 4 mg bid.
Neonates; narrow-angle glaucoma; GI tract/urinary outflow obstruction, paralytic ileus.
Warnings / Precautions
Elderly; caution in driving; peptic ulcer; epilepsy; severe CV disease, benign prostatic hyperplasia; pregnancy and lactation; asthma, bronchitis; hepatic or renal impairment; Parkinson's disease.
Adverse Reactions
Drowsiness, CNS depression, paradoxical excitation (children). Dry mouth, blurring of vision; constipation, retention of urine; bradycardia followed by tachycardia and arrhythmias. GI disturbances; blood dyscrasias; giddiness; hypotension; headache; asthma; tremors; photosensitivity; jaundice; menstrual disorders.
Drug Interactions
Potentiates CNS depressant action of alcohol, barbiturates, hypnotics, opioid analgesics, sedatives and neuroleptics. Antimuscarinic effects potentiated by MAOIs, atropine and TCAs. May reduce effect of levodopa.
See Below for More methdilazine Drug Interactions
Food Interactions
None reported.
Mechanism of Actions
Methdilazine, a phenothiazine derivative, is a sedating antihistamine with antimuscarinic and possibly some serotonin-antagonist properties.
May be taken with or without food.
ATC Classification
R06AD04 - methdilazine ; Belongs to the class of phenothiazine derivatives used as systemic antihistamines.
Available As
  • Methdilazine 2.5 mg
  • Methdilazine 4 mg
  • Methdilazine 8 mg
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