Melitracen

Indications	Oral Depression *Adult:* Initially, 25 mg bid-tid, gradually increased to 225 mg daily if necessary. *Elderly:* Initially, 25 mg daily.
Contraindications	Preexisting CV insufficiency; severe liver disease; children; overactive patients.
Warnings / Precautions	Urinary retention, prostatic hypertrophy, untreated angle-closure glaucoma, pheochromocytoma; history of epilepsy; CV disease; impaired liver function; diabetes; risk of suicide; may precipitate mania or psychotic symptoms when used for CNS disorders; withdraw gradually; may impair ability to operate machinery. Pregnancy and lactation. Elderly.
Adverse Reactions	Restlessness, insomnia, anticholinergic effects, tachycardia, orthostatic hypotension, drowsiness, GI upset, testicular enlargement, impotence. Withdrawal symptoms.
Drug Interactions	Additive toxicity with antimuscarinics, CNS depressants. Response to TCA may be accelerated with thyroid hormones; pressor effects of sympathomimetics may be enhanced; risk of serotonin syndrome when taken with other antidepressants. Antidiabetic dosage may need to be adjusted. See Below for More melitracen Drug Interactions
Mechanism of Actions	Melitracen is a TCA with anxiolytic properties.
ATC Classification	N06AA14 - melitracen ; Belongs to the class of non-selective monoamine reuptake inhibitors. Used in the management of depression.
Available As	Melitracen 0.5 mg Melitracen 10 mg

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