Mebeverine

Indications
 Oral
Irritable bowel syndrome, Gastrointestinal tract spasm
Adult: As hydrochloride: 135 mg tid or 100 mg tid. MR (modified-release) preparation: 200 mg bid. As embonate: 150 mg tid.
Child: As hydrochloride: 3-4 yr: 25 mg; 4-8 yr: 50 mg; 8-10 yr: 100 mg; >10 yr: 135-150 mg. All doses may be given tid. Modified-release preparation: Not recommended.
Contraindications
 Paralytic ileus.
Warnings / Precautions
 Severe hepatic or renal impairment; cardiac disorders e.g. heart block; porphyria. May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
 GI disturbances, dizziness, headache, insomnia, anorexia, decreased heart rate, hypersensitivity reactions.
Overdose Reactions
 See lit.
Mechanism of Actions
 Mebeverine is an antispasmodic agent which exerts direct action on the GI smooth muscle.
Absorption: Rapidly absorbed from the GI tract (oral); peak plasma concentrations within 1-3 hr.
Distribution: Protein-binding: 75% to albumin.
Metabolism: Hydrolysed completely in the liver to veratric acid and mebeverine alcohol.
Excretion: Via urine (as metabolites).
Administration
 Should be taken with food. (Take immediately before or during meals.)
Storage Conditions
 Oral: Conventional prep: Store at or below 30°C. MR (modified-release) prep: Store at 5-25°C.
Storage
 Oral: Conventional prep: Store at or below 30°C. MR (modified-release) prep: Store at 5-25°C.
Available As
  • Mebeverine 135 mg
  • Mebeverine 200 mg

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