Indications |
Oral Dietary supplement Adult: Adjust according to individual requirement. RDA (elemental magnesium): 19-30 yr: Female: 310 mg/day, pregnant female: 350 mg/day, male: 400 mg/day. ≥31 yr: Female: 320 mg/day, pregnant female: 360 mg/day, male: 420 mg/day. |
Warnings / Precautions |
Risk of hypermagnesaemia in patients with renal impairment. Caution in myasthenia gravis. Take with food to reduce incidence of diarrhoea. |
Adverse Reactions |
Gastrointestinal irritation, diarrhoea. |
Overdose Reactions |
Hypermagnesaemia following oral admin is uncommon except in patients with renal impairment. Symptoms of hypermagnesaemia: Respiratory depression and loss of deep tendon reflexes due to neuromuscular blockade; nausea, vomiting, flushing, hypotension, drowsiness, bradycardia and muscle weakness. Treatment: In patients with normal renal function, IV fluids or furosemide may be given to promote Magnesium excretion. In patients with symptomatic hypermagnesaemia, slow IV inj of calcium gluconate can be used to antagonise the cardiac and neuromuscular effects of Magnesium. |
Drug Interactions |
Oral magnesium salts may decrease absorption of bisphosphonates, quinolone antibiotics and tetracycline derivatives; admin should be separated apart if concomitant use is required. Magnesium-containing products may reduce absorption of eltrombopag by 70%; separate admin by at least 4 hr. Calcitriol may increase serum concentrations of Magnesium salts. Magnesium salts may decrease serum concentrations of mycophenolate if used concurrently; monitor for reduced effects of mycophenolate. Concomitant use of trientine and magnesium salt may reduce serum concentrations of both agents. See Below for More magnesium gluconate Drug Interactions |
Mechanism of Actions |
Magnesium is essential to many enzymatic reactions in the body, acting as a cofactor in protein synthesis and carbohydrate metabolism. 17.1 g of Magnesium Gluconate (anhydrous) is equivalent to about 1 g of magnesium. Each g of Magnesium Gluconate (anhydrous) represents about 2.4 mmol of magnesium. Absorption: Oral: About one-third is absorbed from the small intestine. The fraction of magnesium absorbed is inversely proportional to amount ingested. Distribution: Plasma protein binding: About 25-30%. Magnesium crosses the placenta. Excretion: Oral: Via urine (absorbed fraction); faeces (unabsorbed fraction). |
ATC Classification |
A12CC03 - magnesium gluconate ; Belongs to the class of magnesium-containing preparations. Used as dietary supplements. |
Available As |
|
Magnesium Gluconate
Post Review about Magnesium Gluconate Click here to cancel reply.
Magnesium Gluconate Containing Brands
Magnesium Gluconate is used in following diseases
Drug - Drug Interactions of Magnesium Gluconate
Latest News
- FDA approves Ruconest for treatment of hereditary angioedema
- FDA recommend against aspirin to prevent First Heart Attacks
- FDA approves Pomalyst (pomalidomide) for advanced multiple myeloma
- FDA approves three new drug treatments for type 2 diabetes
- Long-term consequences of vaginal delivery on the pelvic floor
No comments yet.