Lubiprostone

Indications	Oral Chronic idiopathic constipation *Adult:* 24 mcg bid.
Contraindications	History of mechanical GI obstruction.
Warnings / Precautions	Safety has not been established in pregnant women. Not to be used in patients with severe diarrhoea.
Adverse Reactions	Dose-dependent nausea. Diarrhoea, abdominal distension, pain, flatulence and vomiting. Headache, dizziness, fatigue, dyspnoea, and peripheral oedema.
Mechanism of Actions	Lupristone is a locally-acting chloride-channel activator that increases intestinal secretion. In doing so, it increases intestinal motility, thus aiding the passage of stool and relieve the symptoms associated with chronic idiopathic constipation. Absorption: Absorption after oral admin is negligible. Metabolism: Rapidly and extensively metabolised by carbonyl reductase, likely in the stomach and jejunum.
Administration	Should be taken with food.
Storage Conditions	Oral: Store between 15-30°C.
ATC Classification	A06AX03 - lubiprostone ; Belongs to the class of other laxatives.
Storage	Oral: Store between 15-30°C.
Available As	Lubiprostone 24 mg Lubiprostone 8 mg

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