Lindane

Indications
 Topical/Cutaneous
Scabies
Adult: Apply a thin layer of 1% topical preparation onto all skin areas from the neck to toes. Completely wash off from the body with warm water after 8-12 hr.
Topical/Cutaneous
Pediculosis
Adult: Apply 30-60 ml of 1% shampoo to dry hair. Amount depends on the length of the hair; most patients will require 30 ml (max 60 ml). Massage into hair for 4 min then add small quantities of water to form a good lather. Immediately rinse thoroughly until all the lather is gone. Dry the hair and comb with a fine tooth comb.
Contraindications
 Hypersensitivity. Uncontrolled seizures; broken skin; premature infant. Lactation.
Warnings / Precautions
 Infants, small children, patients <50 kg, history of seizures or conditions which may increase risk of seizures. Hepatic impairment. Avoid contact with face, eyes, mucous membranes and urethral meatus. Pregnancy.
Adverse Reactions
 Cardiac arrhythmia, ataxia, dizziness, headache, restlessness, seizure, pain, alopecia, contact dermatitis, eczematous eruptions, pruritus, urticaria, nausea, vomiting, aplastic anaemia, hepatitis, burning and stinging, paraesthesia, haematuria, pulmonary oedema.
Potentially Fatal: Severe neurologic toxicities.
Overdose Reactions
 Symptoms: Vomiting, restlessness, ataxia, seizures, arrhythmias, pulmonary oedema, haematuria, hepatitis. Occasionally, severe CNS, hepatic, renal toxicity (excessive use for prolonged periods). Management: Gastric lavage (if ingested) and general supportive measures.
Drug Interactions
 Enhanced absorption and increased risk of toxicity with oils and oil-based preparations.
Potentially Fatal: Increased toxicity with drugs that lower seizure threshold e.g. antidepressants, antipsychotics, ciclosporin, isoniazid.
See Below for More lindane Drug Interactions
Mechanism of Actions
 Lindane stimulates the nervous system of parasites by direct absorption through their exoskeletons causing seizures and death.
Absorption: ≤13% (systemic absorption after topical application); peak plasma concentrations after 6 hr in children.
Distribution: Stored in body fat, accumulates in brain; skin and adipose tissue.
Metabolism: Hepatic.
Excretion: Via urine and faeces; 17-22 hr (elimination half-life in children).
Storage Conditions
 Topical/Cutaneous: Store at controlled room temperature.
ATC Classification
 P03AB02 - lindane ; Belongs to the class of chlorine-containing agents used as ectoparasiticides.
Storage
 Topical/Cutaneous: Store at controlled room temperature.
Available As
  • Lindane 1%
  • Lindane 1% w/v
  • Lindane 1% w/w
  • Lindane 25%

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