Levosulpiride

Indications
 Oral
Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia
Adult: 25 mg tid.
Elderly: Dose reductions may be necessary.

Special Populations: Lower initial doses have been recommended in elderly patients, subsequently adjusted as required. Dosage adjustment is also advised in patients with renal impairment.
Contraindications
 Phaeochromocytoma, epilepsy, manic states, hyperprolactinaemia, mammary dysplasia, malignant mastopathies, cardiac impairment. GI bleeding, mechanical obstruction or perforation.
Warnings / Precautions
 May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
 Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido.
Potentially Fatal: Neuroleptic malignant syndrome.
Drug Interactions
 Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.
See Below for More levosulpiride Drug Interactions
Mechanism of Actions
 Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent.
Absorption: Oral bioavailability is about 30%; peak plasma concentrations after about 3 hr.
Excretion: Mainly via urine. Plasma half-life: 9.7 hr (oral); 4.3 hr (IV).
Storage Conditions
 Oral: Store at 15-30°C (59-86°F).
ATC Classification
 N05AL07 - levosulpiride ; Belongs to the class of benzamides antipsychotics.
Storage
 Oral: Store at 15-30°C (59-86°F).
Available As
  • Levosulpiride 100 mg
  • Sulpiride (Levosulpiride) 100 mg
  • Levosulpiride 12.5 mg
  • Sulpiride (Levosulpiride) 200 mg
  • Levosulpiride 25 mg
  • Sulpiride (Levosulpiride) 400 mg
  • Levosulpiride 50 mg
  • Levosulpiride 75 mg

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    One Response to Levosulpiride

    1. sandeep gurjar March 28, 2013 at 11:45 am #

      sir/madam
      i have completed m.pharma project on LEVOSULPIRIDE 75mg(sustain release tablets) .that reduse tid 25mg that admistrade only one time 75mg so is best reduse side effect…….
      thanks

      sandeep gurjar
      v.po tilawali teh. khetri jhunjhunu(rajasthan)

      Reply

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