Indications |
Oral Parkinsonism Adult: Initially, 125 mg bid; increase gradually every 3-7 days according to response. Max dose: 8 g daily in divided doses. Oral Parkinsonism in conjunction with benserazide Adult: Patients not previously on levodopa therapy: Initially, 50 mg 3 or 4 times daily; gradually increase in increments of 100 mg once or twice wkly. Increase initial dose to 100 mg tid for advanced disease stages. Maintenance dose: 400-800 mg daily in divided doses; most require <600 mg daily. Patients previously on levodopa monotherapy: 10-15% of the usual dose previously taken. Patient previously on other levodopa/dopa-decarboxylase combination therapy: Initially, 50 mg 3 or 4 times daily. Elderly: Initially, 50 mg once or bid, then increase by 50 mg every 3rd or 4th day. Oral Parkinsonism in conjunction with carbidopa Adult: Patients not previously on levodopa therapy: Initially, 25 mg carbidopa with 100 mg levodopa tid; gradually increase in increments of 12.5 mg carbidopa with 50 mg levodopa or 25 mg carbidopa with 100 mg levodopa every day or on alternate days. Maintenance dose: 75-200 mg carbidopa with 750 mg to 2 g levodopa daily in divided doses. Max carbidopa dose: 200 mg daily. Patients previously on levodopa monotherapy: 20-25% of the dose previously taken 3 or 4 times daily. Patient previously on other levodopa/dopa-decarboxylase combination therapy: Initial dose should provide the same daily levodopa dose. |
Contraindications |
Angle-closure glaucoma; malignant melanoma. |
Warnings / Precautions |
Heart disease, liver or renal disease, pulmonary disease, endocrine disorders, seizure disorders, dementia or psychosis; open-angle glaucoma, osteomalacia, history of peptic ulcer. Monitor hepatic, psychiatric, haematological, renal and CV functions periodically. May impair ability to drive or operate machinery. Elderly. Avoid abrupt withdrawal. Pregnancy and lactation. |
Adverse Reactions |
GI disturbances e.g. nausea, vomiting, anorexia. GI bleeding in peptic ulcer patients. Orthostatic hypotension, cardiac arrhythmias. Psychiatric symptoms (especially the elderly), depression with or without suicidal tendency. Abnormal involuntary movements or dyskinesias, delirium, hallucinations. Slight elevation of liver enzymes, BUN and uric acid. Transient leucopenia and thrombocytopenia. |
Overdose Reactions |
Symptoms: Hypertension (initially), hypotension, sinus tachycardia, symptomatic orthostatic hypotension, marked confusion, agitation, insomnia, restlessness, severe anorexia, insomnia. |
Drug Interactions |
Increased postural hypotension and possible reduced absorption with TCAs. Reduced effects with phenothiazines, butyrophenones, thioxanthenes and other antipsychotic agents; reserpine, papaverine, phenytoin, isoniazid. Reversal of effects of levodopa monotherapy with pyridoxine. Exacerbation of abnormal involuntary movements and possibly delayed absorption with anticholinergics. Additive hypotensive effects with antihypertensive agents. Increased CNS toxicity with methyldopa. Exacerbation of parkinsonian symptoms with metoclopramide. Potentially Fatal: Increased risk of hypertensive crises with nonselective MAOIs. Increased risk of cardiac arrhythmias with cyclopropane or halogenated anaesthetics. See Below for More levodopa Drug Interactions |
Lab Interactions |
False-positive Coombs' test. Interferes with serum tests for bilirubin, catecholamines, creatinine, glucose and uric acid and urine tests for creatinine, glucose, ketone and vanillyl mandelic acid (VMA). |
Food Interactions |
Food reduces and delays absorption of levodopa. Effects of levodopa reduced by beans, liver, skimmed milk, yeast and wheat germ. Large neutral amino acids reduce absorption and passage across blood-brain barrier. Recommended to be taken after a light meal to slow absorption and reduce central emetic effect. |
Mechanism of Actions |
Levodopa increases dopamine levels in the brain leading to the stimulation of dopamine receptors. Absorption: Rapidly absorbed from the GI tract (oral); absorption reduced and delayed by food. Peak plasma concentrations within 2 hr. Distribution: Protein-binding: 10-30%. Penetrates the blood-brain barrier; crosses the placenta; distributed into breast milk. Metabolism: Metabolised in the gut, liver and kidney; decarboxylated by L-aminodecarboxylase to dihydrophenylacetic acid (DOPAC) and homovanillic acid (HVA). Other routes: O-methylation, transamination, oxidation. Excretion: Via urine within 24 hr (80% as metabolites); via faeces (minimal amounts). 30-60 min (elimination half-life). |
Administration |
Should be taken with food. (GI discomfort may be reduced by increasing the dose of l-dopa gradually, &/or by taking w/ or after meals. However, taking l-dopa on a full stomach may lead to lower plasma conc. In later disease, it may be preferable to admin on an empty stomach if the patient can tolerate it. Keep a consistent diet. A change in diet to foods high in protein may delay l-dopa absorption & reduce amt taken up in circulation.) |
Storage Conditions |
Oral: Store at 20-25°C (68-77°F). |
ATC Classification |
N04BA01 - levodopa ; Belongs to the class of dopa and dopa derivative dopaminergic agents. Used in the management of Parkinson's disease. |
Storage |
Oral: Store at 20-25°C (68-77°F). |
Available As |
|
Levodopa
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Levodopa Containing Brands
Levodopa is used in following diseases
Drug - Drug Interactions of Levodopa
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