Lanthanum Carbonate

Hyperphosphataemia in end stage renal failure
Adult: Initially, 0.75-2.25 g daily, given in divided doses wth meals. Dose may be adjusted every 2-3 wk until an acceptable serum phosphate concentration is achieved; usual maintenance dose: 1.5-3 g daily in divided doses. Max: 3.75 g daily.
Warnings / Precautions
Caution when used in patients with acute peptic ulcer, ulcerative colitis, Crohn's disease or bowel obstruction. Tablets should be thoroughly chewed before swallowing. Pregnancy and lactation.
Adverse Reactions
GI disturbances, including nausea, vomiting, constipation, diarrhoea, dyspepsia and abdominal pain.
Overdose Reactions
Supportive treatment is recommended.
Drug Interactions
Compounds that are known to interact with antacids should not be taken within 2 hr of administering lanthanum carbonate.
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Lab Interactions
Abdominal x-rays of patients taking lanthanum carbonate may have a radio-opaque appearance typical of an imaging agent.
Mechanism of Actions
Lanthanum carbonate is a non-calcium, non-aluminium phosphate binder used for hyperphosphataemia in patients with chronic renal failure. It works by inhibiting phosphate absorption by forming highly insoluble lanthanum phosphate complexes, thus reducing both serum phosphate and calcium phosphate product.
Distribution: Highly bound to plasma proteins.
Metabolism: Not metabolised.
Excretion: Eliminated mainly by the biliary system. Elimination half life: Approx 36 hr.
Should be taken with food. (Take w/ or immediately after meals. Chew thoroughly before swallowing. Do not swallow whole.)
Storage Conditions
Oral: Store at 15-30°C.
ATC Classification
V03AE03 - lanthanum carbonate ; Belongs to the class of drugs used in the treatment of hyperkalemia and hyperphosphatemia.
Oral: Store at 15-30°C.
Available As
  • Lanthanum Carbonate 250 mg
  • Lanthanum Carbonate 500 mg
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