Lafutidine

Indications
 Oral
Gastric and duodenal ulcers
Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient's age and symptoms.
Elderly: Dose reduction or increase in dosing interval may be needed.
Renal impairment: Dose reduction or increase in dosing interval may be needed.
Hepatic impairment: Dose reduction or increase in dosing interval may be needed.
Oral
Stomal ulcers
Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient's age and symptoms.
Elderly: Dose reduction or increase in dosing interval may be needed.
Renal impairment: Dose reduction or increase in dosing interval may be needed.
Hepatic impairment: Dose reduction or increase in dosing interval may be needed.
Oral
Gastric mucosal lesions
Adult: 10 mg once daily, after evening meal or before sleeping. Adjust dose according to patient's age and symptoms.
Elderly: Dose reduction or increase in dosing interval may be needed.
Renal impairment: Dose reduction or increase in dosing interval may be needed.
Hepatic impairment: Dose reduction or increase in dosing interval may be needed.
Oral
Pre-anaesthetic medication
Adult: 10 mg before sleeping on the day before operation, and 10 mg 2 hr before introduction of anaesthetic on the day of operation.
Elderly: Dose reduction or increase in dosing interval may be needed.
Renal impairment: Dose reduction or increase in dosing interval may be needed.
Hepatic impairment: Dose reduction or increase in dosing interval may be needed.
Contraindications
 Lactation.
Warnings / Precautions
 Hepatic and renal impairment. Elderly.
Adverse Reactions
 Constipation, hyperuricaemia, increase in LFT and total bilirubin, gynaecomastia, anorexia, hallucinations.
Potentially Fatal: Anaphylactic reactions, blood dyscrasias (e.g. agranulocytosis, thrombocytopenia).
Mechanism of Actions
 Lafutidine is a histamine H2-antagonist with gastroprotective activity. It is used in the treatment of gastric ulcers and before general anaesthesia to reduce the incidence of aspiration pneumonia.
Distribution: Protein binding: 88%.
Metabolism: Metabolised by CYP3A4 (mainly) and CYP2D6.
Excretion: Excreted in urine as unchanged drug and metabolites
ATC Classification
 A02BA08 - lafutidine ; Belongs to the class of H2-receptor antagonists. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Available As
  • Lafutidine 10 mg
  • Lafutidine 5 mg

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