Isosorbide 5 Mononitrate

Indications
 Oral
Management of angina, Heart failure
Adult: 20 mg 2-3 times daily. Dose may range from 20-120 mg daily.
Elderly: Intiate at lower doses.
Contraindications
 Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.
Warnings / Precautions
 Severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. Caution in patients who are already hypotensive. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance may develop after long-term treatment. Lactation.
Adverse Reactions
 Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence.
Potentially Fatal: Severe hypotension and cardiac failure.
Overdose Reactions
 Symptoms: Increased intracranial pressure, with or without persistent throbbing headache, confusion and moderate fever, vertigo, palpitations, visual disturbances, nausea and vomiting.
Drug Interactions
 Hypotensive effects may be increased when used with alcohol or vasodilators. Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension.
Potentially Fatal: Significant hypotension may occur when used with phosphodiesterase-5 inhibitors.
See Below for More isosorbide mononitrate Drug Interactions
Lab Interactions
 False decrease in serum cholesterol.
Mechanism of Actions
 Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).
Onset: 20 min (oral as conventional tab).
Duration: 8-10 hr (oral as conventional tab).
Absorption: Readily absorbed from the GIT (oral); peak plasma concentrations after 1 hr.
Distribution: Widely distributed: Smooth muscle cells of the blood vessels.
Metabolism: Converted to inactive metabolites including isosorbide and isosorbide glucuronide.
Excretion: Via urine (2% as unchanged); 4-5 hr (elimination half-life).
Administration
 Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food).
Storage Conditions
 Oral: Store at 20-25°C.
ATC Classification
 C01DA14 - isosorbide mononitrate ; Belongs to the class of organic nitrate vasodilators. Used in the treatment of cardiac disease.
Storage
 Oral: Store at 20-25°C.
Available As
  • Isosorbide-5 Mononitrate 10 mg
  • Isosorbide 5 Mononitrate 10 mg
  • Isosorbide Mononitrate 10 mg
  • Isosorbide Dinitrate 10 mg
  • Isosorbide 5 Mononitrate 20 mg
  • Isosorbide Mononitrate 20 mg
  • Isosorbide-5 Mononitrate 20 mg
  • Isosorbide Dinitrate 20 mg
  • Isosorbide Dinitrate 25 mg
  • Isosorbide 5 Mononitrate 25 mg
  • Isosorbide Mononitrate 25 mg
  • Isosorbide Dinitrate 30 mg
  • Isosorbide 5 Mononitrate 30 mg
  • Isosorbide-5 Mononitrate 30 mg
  • Isosorbide Mononitrate 30 mg
  • Isosorbide Dinitrate 40 mg
  • Isosorbide-5 Mononitrate 40 mg
  • Isosorbide 5 Mononitrate 40 mg
  • Isosorbide Mononitrate 40 mg
  • Isosorbide Dinitrate 5 mg
  • Isosorbide 5 Mononitrate 50 mg
  • Isosorbide Mononitrate 50 mg
  • Isosorbide Mononitrate 60 mg
  • Isosorbide-5 Mononitrate 60 mg
  • Isosorbide 5 Mononitrate 60 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Isosorbide 5 Mononitrate


    Isosorbide 5 Mononitrate Containing Brands

    We are Developing Our database, More results coming soon.

    Isosorbide 5 Mononitrate is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Isosorbide 5 Mononitrate

    We are Developing Our database, More results coming soon.

    Isosorbide-5 Mononitrate

    Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Isosorbide-5 Mononitrate


    Isosorbide-5 Mononitrate Containing Brands

    We are Developing Our database, More results coming soon.

    Isosorbide-5 Mononitrate is used in following diseases
    Drug - Drug Interactions of Isosorbide-5 Mononitrate

    We are Developing Our database, More results coming soon.