Irbesartan

Indications
 Oral
Hypertension
Adult: 150 mg once daily, increased to 300 mg once daily if necessary. For patients with intravascular volume depletion: Initially, 75 mg once daily.
Child: 6-16 yr: 75 mg once daily increased to 150 mg if necessary.
Elderly: >75 yr: Initially 75 mg once daily.
Renal impairment: Haemodialysis: Initially, 75 mg once daily.
Oral
Diabetic nephropathy in Type 2 diabetes mellitus
Adult: 150 mg once daily, increased to 300 mg once daily if necessary.

Special Populations: Patients with intravascular vol depletion and those undergoing haemodialysis: Initially, 75 mg once daily.
Contraindications
 Hypersensitivity; pregnancy and lactation.
Warnings / Precautions
 Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy.
Adverse Reactions
 Diarrhoea, dizziness, fatigue, headache, hyperkalaemia. Dyspepsia, oedema, myalgia, insomnia, nasal congestion, 1st dose orthostatic hypotension, rash, pharyngitis, urticaria, angioedema, anxiety/nervousness, tachycardia.
Drug Interactions
 Potassium or potassium-sparing diuretics may increase risk of hyperkalaemia. NSAIDs may reduce antihypertensive response. Excretion of lithium may be reduced, monitor lithium concentrations.
See Below for More irbesartan Drug Interactions
Mechanism of Actions
 Irbesartan is an angiotensin II type I receptor antagonist and therefore blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II.
Absorption: Rapidly absorbed from the GIT (oral); peak plasma concentrations are achieved after 1.5-2 hrs.
Distribution: Protein-binding around 96%
Metabolism: Some hepatic metabolism via cytochrome P450 isoenzyme CYP2C9 to inactive metabolites.
Excretion: Via bile and urine (as unchanged drug and metabolites); via urine (20% of IV dose, <2% as unchanged). 11-15 hrs (elimination half-life).
Administration
 May be taken with or without food.
ATC Classification
 C09CA04 - irbesartan ; Belongs to the class of angiotensin II antagonists. Used in the treatment of cardiovascular disease.
Available As
  • Irbesartan 150 mg
  • Irbesartan 300 mg

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