Interferon Alpha-2B

Indications
 Parenteral
Chronic active hepatitis B
Adult: 5-10 million units IM/SC 3 times wkly for 4-6 mth, or 5 million units daily for 16 wk.
Parenteral
Chronic hepatitis C
Adult: 3 million units IM/SC 3 times wkly for 6-12 mth (depending on genotype) when used with ribavirin, or for 6-18 mth (up to 24 mth) when used as monotherapy.
Parenteral
AIDS-related Kaposi's sarcoma
Adult: 30 million units/m2 IM/SC 3 times wkly.
Parenteral
Hairy cell leukaemia
Adult: 2 million units/m2 IM/SC 3 times wkly for up to 6 mth or more.
Subcutaneous
Chronic myeloid leukaemia
Adult: 4-5 million units/m2 daily; continue at the max tolerated dose to maintain remission.
Max Dosage: 4-10 million units/m2 daily.
Subcutaneous
Follicular lymphoma
Adult: As an adjunct to chemotherapy: 5 million units 3 times wkly for 18 mth.
Subcutaneous
Carcinoid tumours
Adult: 3-9 million units (usually 5 million units) 3 times wkly. Advanced disease: 5 million units daily.
Parenteral
Melanoma
Adult: Initially, 20 million units/m2 daily for 5 days each wk for 4 wk by IV infusion over 20 minutes. Maintenance: 10 million units/m2 via SC inj 3 times wkly for 48 wk.
Subcutaneous
Multiple myeloma
Adult: Maintenance dose following chemotherapy induction: 3 million units/m2 3 times wkly.
Injection
Condyloma acuminata
Adult: Inject 1 million units into each lesion 3 times wkly for 3 wk; repeat after 12-16 wk as needed. Max: 5 lesions per treatment course.
Contraindications
 Hypersensitivity. Hepatic decompensation, autoimmune hepatitis or a history of autoimmune disease, immunosuppressed transplant recipients.
Warnings / Precautions
 History of pulmonary disease (e.g. COPD) or DM prone to ketoacidosis. Coagulation disorders or severe myelosuppression. Monitor patients with history of MI and/or arrhythmic disorders. Preexisting or history of psychiatric disorder, particularly depression. Poorly controlled thyroid abnormalities. Perform ophthalmological exam on patients with preexisting ophthalmologic disorders (e.g. diabetic or hypertensive retinopathy). Monitor WBC count in myelosuppressed patients and in those receiving other myelosuppressive agents. Preexisting psoriasis. May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
 Flu-like symptoms; alopecia; hypersensitivity reactions; nausea; anorexia; myelosuppression; lethargy; ocular side effects; depression; CV problems; nephrotoxicity; hypertriglyceridaemia; thyroid abnormalities; hyperglycaemia; psoriasiform rash; confusion; coma; seizures.
Potentially Fatal: Hepatotoxicity, pulmonary infiltrates, pneumonitis and pneumonia, autoimmune diseases.
Drug Interactions
 Reduces clearance of theophylline. Enhanced myelosuppression with other myelosuppressive drugs (e.g. zidovudine).
See Below for More interferon alfa-2b Drug Interactions
Mechanism of Actions
 Interferon alfa-2b binds to a specific cell surface protein. Once bound, it initiates a series of intracellular activities including induction of certain enzymes, suppression of cell proliferation, enhancement of phagocytic activity of macrophages, augmentation of cytotoxicity of lymphocytes for target cells, and inhibition of viral replication.
Absorption: Peak plasma concentrations in 3-12 hr (IM/SC); 30 min (IV).
Excretion: Elimination half-life: 2-3 hr (IM/SC); 2 hr (IV).
Storage Conditions
 Injection: Store at 2-8°C (36-46°F). Parenteral: Store at 2-8°C (36-46°F). Subcutaneous: Store at 2-8°C (36-46°F).
ATC Classification
 L03AB05 - interferon alfa-2b ; Belongs to the class of interferons. Used as immunostimulants.
Storage
 Injection: Store at 2-8°C (36-46°F). Parenteral: Store at 2-8°C (36-46°F). Subcutaneous: Store at 2-8°C (36-46°F).
Available As
  • Interferon Alpha-2B 3 million iu
  • Interferon Alpha-2B 5 million iu

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