Insulin (Analogue) Lispro

Indications
 Subcutaneous
Diabetes mellitus
Adult: Dosing regimen should be individualised and adjusted based on patient's glycaemic response. Administer 15 min before or immediately after a meal.
Renal impairment: Decreased dose may be necessary.
Hepatic impairment: Decreased dose may be necessary.

Special Populations: Renal impairment: CrCl 10-50 mL/min: 75% of normal dose; <10 mL/min: 25-50% of normal dose and monitor glucose closely.
Contraindications
 Hypoglycaemia.
Warnings / Precautions
 Renal or hepatic impairment; pregnancy, lactation; transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections.
Adverse Reactions
 Hypoglycaemia; oedema; pruritus; rash; hypersensitivity reactions; lipoatropy or lipohypertrophy with SC Inj (rotate Inj site).
Drug Interactions
 Effects may be increased by: oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog (e.g., octreotide), sulfonamide antibiotics. Effects may be decreased by: corticosteroids, niacin, danazol, diuretics, sympathomimetic agents, isoniazid, phenothiazine derivatives, somatropin, thyroid hormones, oral contraceptives, lithium. Signs of hypoglycaemia may be masked by β-blockers, clonidine.
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Mechanism of Actions
 Insulin lispro, a rapid-acting analog of human insulin, lowers blood glucose levels. It regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.
Onset: 15-30 min
Duration: 3-6.5 hrs.
Administration
 Should be taken with food. (Administer w/in 15 min before or immediately after meals.)
ATC Classification
 A10AB04 - insulin lispro ; Belongs to the class of fast-acting insulins and analogues. Used in the treatment of diabetes.
A10AC04 - insulin lispro ; Belongs to the class of intermediate-acting insulins and analogues. Used in the treatment of diabetes.
A10AD04 - Insulin lispro ; Belongs to the class of intermediate-acting combined with fast-acting insulins and analogues. Used in the treatment of diabetes.
Available As
  • Insulin (Analogue) Lispro 100 iu

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