Imiquimod

Indications
 Topical/Cutaneous
Condyloma acuminata
Adult: As 5% cream: Apply 3 times wkly for up to 16 wk. Cream is applied at night and left on the skin for 6-10 hr. Wash with mild soap and water after each dose.
Topical/Cutaneous
Perianal warts
Adult: As 5% cream: Apply 3 times wkly for up to 16 wk. Cream is applied at night and left on the skin for 6-10 hr. Wash with mild soap and water after each dose.
Topical/Cutaneous
Actinic keratoses
Adult: As 5% cream: Apply 3 times wkly for 4 wk. May repeat for a further 4 wk after a 4-wk break if needed. Cream is applied at night and left on the skin for approx 8 hr. Wash w/ mild soap and water after use.
Topical/Cutaneous
Superficial basal cell carcinoma
Adult: As 5% cream: Apply 5 times wkly for 6 wk. Cream is applied at night and left on the skin for approx 8 hr. Wash skin w/ mild soap and water after each dose.
Warnings / Precautions
 Avoid normal skin, inflamed skin and open wounds. Not for internal genital warts. Risk of phimosis or stricture of foreskin in uncircumcised males. May increase risk of photosensitivity; patients should protect themselves from sun and UV light exposure. Pregnancy and lactation.
Adverse Reactions
 Erythema, skin erosion, excoriation, flaking, oedema, pain, itching, rarely local ulceration and scabbing; permanent hypo- or hyperpigmentation; headache, influenza-like symptoms and myalgia.
Mechanism of Actions
 Imiquimod is an immune response modifier; may induce cytokines. The exact mechanism of action is unknown.
Absorption: Absorption is minimal.
Excretion: Urine (≤2% of aplied dose as parent drug and metabolites.)
ATC Classification
 D06BB10 - imiquimod ; Belongs to the class of topical antivirals used in the treatment of dermatological diseases.
Available As
  • Imiquimod 5%

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