Hyaluronidase

Indications
 Parenteral
Adjunct in hypodermoclysis
Adult: 1500 units for every 500-1000 ml of fluid for SC admin.
Parenteral
Facilitate SC/IM injections
Adult: 1500 units directly added to the inj.
Parenteral
Aid in the dispersal of extravasated fluids or blood
Adult: 1500 units in 1 ml of water for inj or normal saline is injected into the affected area.
Parenteral
Aid in the diffusion of local anaesthetic in ophthalmology
Adult: 15 units/ml of local anaesthetic solution.

Incompatibility: Physical incompatibility has been reported with heparin and adrenaline, frusemide, benzodiazepines and phenytoin.
Contraindications
 Hypersensitivity, malignancy. Direct application to the cornea, reduction of swelling of bites or stings. Inj into or around infected area. IV admin; unexplained premature labour.
Warnings / Precautions
 Impaired renal function. Infants, elderly. Patients with infections. Pregnancy, lactation.
Adverse Reactions
 Urticaria, occasional severe allergy.
Potentially Fatal: Hypersensitivity and anaphylaxis.
Overdose Reactions
 Symptoms include hypotension, tachycardia, headache and generalised skin flushing. Other complications may include myocardial ischaemia and subsequent MI, cardiac arrhythmia and profound shock. Treatment is supportive and symptomatic.
Drug Interactions
 Action potentiated by urokinase especially in the treatment of MI. May increase absorption and toxicity of local anaesthetics. Heparin, salicylates and NSAIDs may inhibit the spreading action and efficacy of hyaluronidase.
See Below for More hyaluronidase Drug Interactions
Mechanism of Actions
 Hyaluronidase is an enzyme which reduces the viscosity of ground substance, thus making the tissues more permeable to injected fluids. It facilitates distribution and absorption of locally injected substances. It also promotes resorption of excess fluids and extravasated blood in the tissues.
Storage Conditions
 Parenteral: Refrigerate at 2-8°C.
ATC Classification
 B06AA03 - hyaluronidase ; Belongs to the class of enzymes used as hematological agent.
Storage
 Parenteral: Refrigerate at 2-8°C.
Available As
  • Hyaluronidase 1500 iu

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