Human Anti-D Immoune globulin

Indications
 Intramuscular
Prevent formation of antibodies against foetal rhesus-positive RBCs in a rhesus-negative mother during childbirth, abortion or certain other sensitising events
Adult: 500 units as soon as possible after birth. An additional dose may be required depending on the amount of transplacental bleeding as assessed by the Kleihauer test; for bleeds >4 ml, an additional 125 units for each ml of RBCs will be required.
Intramuscular
Routine antenatal prophylaxis
Adult: 2 doses of 500 units to be given at wk 28th and 34th of gestation.
Intramuscular
Transfusion of D-positive blood components to rhesus-negative women of child-bearing potential
Adult: 125 units/ml of transferred cells.
Intravenous
Idiopathic thrombocytopenic purpura
Adult: Initially, 250 units/kg, may be given in 2 divided doses on separate days. Maintenance doses: 125-300 units/kg depending on the clinical response.
Contraindications
 Splenectomised or rhesus-negative patients, in whom the resultant haemolysis may exacerbate pre-existing anaemia. Hypersensitivity.
Warnings / Precautions
 For postpartum usage, it is to be used only for maternal admin. Not for rhesus-positive individuals. Patients should be observed for 20 minutes after admin.
Adverse Reactions
 Hypersensitivity reactions such as hives, wheezing, urticaria, Pain and tenderness at inj site. Fever, chills, nausea, facial flushing, headache.
Potentially Fatal: Intravascular haemolysis. Anaphylaxis reactions.
Drug Interactions
 Live vaccines should only be admin at least 3 mth after the last dose of immunoglobulin admin.
See Below for More anti-d immunoglobulins Drug Interactions
Lab Interactions
 May affect the results of blood typing and antibody testing such as Coomb's test or antiglobulin test.
Mechanism of Actions
 Anti-D immunoglobulin prevents a rhesus-negative mother from actively forming antibodies to foetal rhesus-positive RBCs that may pass into the maternal circulation during childbirth, abortion, or certain other sensitising events. It is also used in idiopathic thrombocytopenic purpura to prevent excessive bleeding.
Available As
  • Human Anti-D Immoune globulin 100 mcg
  • Human Anti-D Immoune globulin 1250 iu
  • Human Anti-D Immoune globulin 250 mcg
  • Human Anti-D Immoune globulin 300 iu
  • Human Anti-D Immoune globulin 300 mcg
  • Human Anti-D Immoune globulin 50 mcg

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