Goserelin

Indications
 Subcutaneous
Palliative treatment of prostatic carcinoma
Adult: 3.6 mg injected into the anterior abdominal wall every 28 days or 10.8 mg every 12 wk. An anti-androgen is given several days before beginning of the treatment and continued for at least 3 wk to prevent disease flare.
Subcutaneous
Pituitary desensitisation before ovulation induction with gonadotrophins
Adult: 3.6 mg as a depot inj. Monitor serum-oestradiol concentrations until they decline to levels similar to those in the early follicular phase which takes about 7-21 days.
Contraindications
 Hypersensitivity; pregnancy, lactation.
Warnings / Precautions
 Urinary tract obstruction or spinal cord compression (when used for prostate cancer); decreased bone density in women. Contraceptive measures should be taken to protect against pregnancy. Monitor men at risk from tumour flare during the 1st mth of therapy. Safety and efficacy on the usage of the 10.8 mg implant in women is not established.
Adverse Reactions
 Vaginal bleeding and dryness, arthralgia, paraesthesias, increase in menstrual bleeding, hot flushes, sexual dysfunction. Headache, emotional lability, depression, insomnia, diaphoresis, dizziness, breast swelling/tenderness, Inj site reactions. Anaphylaxis.
Mechanism of Actions
 Goserelin is a potent inhibitor of pituitary gonadotrophin secretion. Initially, it causes an increase in the serum levels of FSH and LH but chronic admin will lead to sustained suppression of the pituitary gonadotrophin release causing regression of the sex organs.
Absorption: Almost complete (SC).
Excretion: >90% excreted in urine (as unchanged drug and metabolites); 2-4 hr (elimination half-life).
Storage Conditions
 Subcutaneous: Store below 25°C.
ATC Classification
 L02AE03 - goserelin ; Belongs to the class of gonadotropin releasing hormone analogues. Used in endocrine therapy.
Storage
 Subcutaneous: Store below 25°C.
Available As
  • Goserelin 10.8 mg
  • Goserelin 3.6 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Goserelin


    Goserelin Containing Brands

    We are Developing Our database, More results coming soon.

    Goserelin is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Goserelin

    We are Developing Our database, More results coming soon.