Gemfibrozil

Indications
 Oral
Hyperlipidaemias
Adult: 1.2 g daily in 2 divided doses. Maintenance: 0.9-1.5 g daily.
Contraindications
 Hypersensitivity. Severe hepatic or renal dysfunction; gall stones; neonates, children, pregnancy, lactation.
Warnings / Precautions
 Causes of secondary hyperlipidaemia such as hypothyroidism and diabetes must be treated before initiating therapy. Renal impairment; blood disorders. Periodic monitoring of the serum lipids should be done; if no adequate response after 3 mth, treatment should be withdrawn. May increase risk of cholelithiasis.
Adverse Reactions
 Myositic syndrome, cholelithiasis, GI disturbances, rash, headache, blood dyscrasias, myalgia. Impotence, painful extremities, blurred vision; pruritus, urticaria; impotence; dizziness; cholestatic jaundice.
Potentially Fatal: Bone marrow hypoplasia; intracranial haemorrhage; nephrotoxicity; peripheral neuritis.
Drug Interactions
 Co-admin with repaglinide may increase serum levels of repaglinide. May enhance effects of oral anticoagulants. May also increase the plasma concentrations of ciclosporin and associated nephrotoxicity when used concurrently.
Potentially Fatal: Increased risk of myopathy and rhabdomyolysis when used with HMG-CoA reductase inhibitors.
See Below for More gemfibrozil Drug Interactions
Lab Interactions
 May cause elevations of AST, ALT, bilirubin, and alkaline phosphatase.
Mechanism of Actions
 Gemfibrozil exhibits its action by inhibition of lipolysis and reduction of hepatic fatty acid uptake. It also inhibits secretion of VLDL from the liver.
Absorption: Readily absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hr.
Distribution: Protein-binding: 80%.
Metabolism: Hepatic via oxidation; undergoes enterohepatic recirculation.
Excretion: Urine (70% glucuronide conjugates and metabolites); faeces (small amounts); 1.5 hr (elimination half-life).
Administration
 Should be taken on an empty stomach. (Take ½ hr before meals.)
Storage Conditions
 Oral: Store below 30°C.
ATC Classification
 C10AB04 - gemfibrozil ; Belongs to the class of fibrates. Used in the treatment of hyperlipidemia.
Storage
 Oral: Store below 30°C.
Available As
  • Gemfibrozil 300 mg
  • Gemfibrozil 600 mg
  • Gemfibrozil 900 mg

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