Galantamine

Indications
 Oral
Alzheimer's dementia
Adult: Initially, 4 mg bid for 4 wk increased to 8 mg bid for at least 4 wk. May further increase to 12 mg bid based on response and tolerance.
Renal impairment: Moderate: Max: 16 mg daily.
CrCl (ml/min)Dosage Recommendation
<9Avoid.
Hepatic impairment: Child-Pugh category C: Avoid.

Special Populations: Moderate hepatic or renal impairment: Reduce dose. Max Dose: 16 mg/day.
Contraindications
 Hypersensitivity; severe liver or kidney dysfunction; lactation; disorders of galactose metabolism; urinary retention or GI obstruction. Lactation.
Warnings / Precautions
 Mild-moderate hepatic impairment; supraventricular conduction abnormalities; asthma; COPD; pregnancy; peptic ulcers. May increase gastric acid production.
Adverse Reactions
 GI disturbances; bradycardia, CNS disturbances; tremor, anorexia, wt loss; urinary tract infection; anaemia; rhinitis.
Potentially Fatal: CV effects; convulsion; delirium; rectal haemorrhage; thrombocytopenia.
Drug Interactions
 Increased serum concentrations when used with drugs that inhibit CYP2D6 (e.g. quinidine, fluoxetine, fluvoxamine, and paroxetine) and CYP3A4 (e.g. ketoconazole and ritonavir). Cimetidine may increase the bioavailability of galantamine. Increased risk of gastric ulcer when used with NSAIDs.
Potentially Fatal: Amiodarone, β-blockers, diltiazem or verapamil; NSAIDs; digoxin.
See Below for More galantamine Drug Interactions
Lab Interactions
 Alkaline phosphatase level may increase.
Food Interactions
 Avoid alcohol and St John's wort.
Mechanism of Actions
 Galantamine is a centrally-acting cholinesterase inhibitor, elevating acetylcholine in the cerebral cortex. Glutamine and serotonin levels may also be increase. It has nicotinic receptor agonist properties.
Duration: 3 hr.
Absorption: Well absorbed from the GI tract.
Distribution: Protein binding: About 18%.
Metabolism: Partly metabolised by CYP2D6 and CYP3A4.
Excretion: Elimination half-life: About 7-8 hr.
Administration
 Should be taken with food.
Storage Conditions
 Oral: Store at 25°C.
ATC Classification
 N06DA04 - galantamine ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Storage
 Oral: Store at 25°C.
Available As
  • Galantamine 4 mg
  • Galantamine 8 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Galantamine


    Galantamine Containing Brands

    We are Developing Our database, More results coming soon.

    Galantamine is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Galantamine

    We are Developing Our database, More results coming soon.