Palliative treatment of prostatic carcinoma
Adult: 250 mg tid preferably at least 3 days before gonadorelin analogue treatment.
Hypersensitivity, severe hepatic impairment, pregnancy and lactation.
Warnings / Precautions
Perform liver function tests before starting treatment and at regular intervals. Treatment is not recommended in patients whose ALT values exceed twice the upper limit of normal. Regular assessment of prostate specific antigen level may help to monitor disease progression. Advise patient against discontinuing drug on their own. Exercise caution in patients with cardiac disease.
Adverse Reactions
Hot flushes, loss of libido, impotence, gynaecomastia, nausea, vomiting, diarrhoea, increased appetite, sleep disturbances, skin reactions, anaemias, headache, dizziness, malaise, anxiety, hypertension, gastric and chest pain, oedema, blurred vision, hepatitis, jaundice, rash, thirst, pruritus, SLE-like syndrome, drowsiness, confusion, depression, nervousness.
Drug Interactions
Increased prothrombin time in patients on long-term warfarin treatment.
See Below for More flutamide Drug Interactions
Mechanism of Actions
Flutamide is a nonsteroidal 'pure' antiandrogen which acts directly on the target tissues either by blocking androgen uptake or by inhibiting cytoplasmic and nuclear binding of androgen.
Distribution: Protein-binding: 90%
Metabolism: Rapid and extensive; converted to hydroxyflutamide.
Excretion: Urine, faeces (small amounts); 2 hrs (elimination half-life, metabolite).
Storage Conditions
Oral: Store at 25°C.
ATC Classification
L02BB01 - flutamide ; Belongs to the class of anti-androgens.
Oral: Store at 25°C.
Available As
  • Flutamide 250 mg
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