Fluorometholone

Indications
 Ophthalmic
Allergic and inflammatory conditions of the eye
Adult: As 0.1% ointment: Apply 1/2 inch ribbon to the conjunctival sac 1-3 times daily. As 0.1% solution: Instil 1-2 drops into the conjunctival sac 2-4 times daily. Dosage may be increased to every 4 hr in severe cases during the initial 24-48 hr. Re-evaluate if no signs of improvement after 48 hr of treatment.
Child: >2 yr: As 0.1% ointment: Apply 1/2 inch ribbon to the conjunctival sac 1-3 times daily. As 0.1% solution: Instil 1-2 drops into the conjunctival sac 2-4 times daily. Dosage may be increased to every 4 hr in severe cases during the initial 24-48 hr. Re-evaluate if no signs of improvement after 48 hr of treatment.
Contraindications
 Viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), Vaccinia and Varicella, mycobacterial eye infection, ocular fungal infections, untreated eye infections; hypersensitivity.
Warnings / Precautions
 Glaucoma (check intraocular pressure periodically), history of herpes simplex fungal or bacterial infections. Not to be used in mustard gas keratitis and Sjogren's keratoconjunctivitis. May cause corneal and scleral thinning which may lead to perforation in serious cases. Use of steroids after cataract surgery may prolong healing time and increase bleb formation. Pregnancy, lactation; children <2 yr.
Adverse Reactions
 Elevated intraocular pressure, optic nerve damage, postsubcapsular cataract formation, delayed wound healing, uveitis, perforation of the globe, keratitis, conjunctivitis, corneal ulcers, loss of accommodation, secondary ocular infections, rarely systemic hypercorticoidism.
Mechanism of Actions
 Fluorometholone suppresses the migration of polymorphonuclear leukocytes and reversal of increased capillary permeability thus decreasing inflammation.
Absorption: Into aqueous humor; slight systemic absorption.
Storage Conditions
 Ophthalmic: Store below 25°C.
ATC Classification
 C05AA06 - fluorometholone ; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids and anal fissures.
D07AB06 - fluorometholone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
D07XB04 - fluorometholone ; Belongs to the class of moderately potent (group II) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
D10AA01 - fluorometholone ; Belongs to the class of topical corticosteroids used in the treatment of acne.
S01BA07 - fluorometholone ; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.
S01CB05 - fluorometholone ; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases.
Storage
 Ophthalmic: Store below 25°C.
Available As
  • Fluorometholone 0.1%
  • Fluorometholone 0.1% w/v
  • Fluorometholone 0.25%
  • Fluorometholone 1 mg
  • Fluorometholone USP 1 mg
  • Fluorometholone USP 1%
  • Fluorometholone 1% w/v

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