Flunisolide

Indications
 Nasal
Treatment and prophylaxis of allergic rhinitis
Adult: Per metered spray contains 25 mcg: Initially, 2 sprays into each nostril bid, may increase to tid if needed, then reduce for maintenance.
Child: 5-14 yr: Per metered spray contains 25 mcg: 1 spray into each nostril up to tid.
Inhalation
Asthma
Adult: As a metered-dose aerosol using chlorofluorocarbon (CFC) propellant: 500 mcg bid up to 2 mg/day in severe asthma.
Child: >6-15 yr: As a metered-dose aerosol using chlorofluorocarbon (CFC) propellant: Not to exceed 500 mcg bid.
Contraindications
 Hypersensitivity; presence of untreated acute infections; active or quiscent tuberculosis; ulcerative conditions.
Warnings / Precautions
 Congestive heart failure; recent myocardial infarction; hypertension; diabetes mellitus; epilepsy; glaucoma; hypothyroidism; osteoporosis; peptic ulceration; psychoses; renal or hepatic impairment; elderly; childn; pregnancy and lactation.
Adverse Reactions
 Osteoporosis; muscle wasting; hyperglycaemia; impaired tissue repair; delayed wound healing; amenorrhoea, hyperhidrosis; ocular changes; mental and neurological disturbances; increased susceptiblity to infections.
Drug Interactions
 GI bleeding and ulceration with NSAIDs. Decreased serum concentrations of salicylates. Decreased effect with barbiturates, carbamezepine, pheytoin, primidone or rifampicin.
Potentially Fatal: Hypokalaemia with potassium-depleting drugs such as thiazide, furosemide or amphotericin B.
See Below for More flunisolide Drug Interactions
Mechanism of Actions
 Flunisolide exerts glucocorticoid activity exhibiting potent anti-inflammatory and immunosuppressive effects, at least partly through inhibition of the release of various cytokines.
Absorption: Absorbed following intranasal administration.
Metabolism: Extensive 1st pass metabolism (only 20% of dose systemically available); converted to 6β-hydroxyflunisolide (has little glucocorticoid activity).
Excretion: 4 hrs (elimination half-life).
Storage Conditions
 Inhalation: Store at 15-25°C. Nasal: Store at 15-25°C.
ATC Classification
 R01AD04 - flunisolide ; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.
R03BA03 - flunisolide ; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticoids.
Storage
 Inhalation: Store at 15-25°C. Nasal: Store at 15-25°C.
Available As
  • Flunisolide 0.025% w/v

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