Primary adrenocortical insufficiency
Adult: 50-300 mcg daily, may range from 100 mcg 3 times/wk to 200 mcg/day. In Addison's disease, initiate with 100 mcg daily, may reduce dose to 50 mcg daily if hypertension occurs; to be used in combination with cortisone or hydrocortisone.
Child: 50-100 mcg daily.
Salt-losing adrenogenital hyperplasia
Adult: Up to 200 mcg daily.
Hypersensitivity. Hyperalbuminaemia; hypertension, systemic fungal infections.
Warnings / Precautions
Addison's disease, fluid retention and hypokalaemia. Pregnancy, lactation, children and elderly.
Adverse Reactions
Hypertension, sodium and water retention, potassium loss, dizziness, itching, skin rash, headache, convulsions, CHF, muscle weakness, hyperglycaemia, HPA and growth suppression, peptic ulcer, cataracts, raised intraocular pressure and reduced visual acuity.
Drug Interactions
May decrease salicylate levels. Anticholinesterase effects are antagonised. Decreased effects with rifampin, barbiturates, hydantoins and phenytoin. Oral contraceptives or ritonavir may increase the plasma concentrations of fludrocortisone. Increased potassium loss with potassium-depleting drugs e.g. thiazides, furosemide or amphotericin B. Increased risk of GI bleeding or ulceration with NSAIDs. May alter efficacy of anticoagulants when used concurrently.
See Below for More fludrocortisone Drug Interactions
Mechanism of Actions
Fludrocortisone promotes reabsorption of sodium and urinary excretion of potassium and hydrogen ions from renal distal tubules.
Absorption: Rapid and complete (oral). Peak plasma concentrations after 1.7 hr.
Distribution: Protein-binding: 42%.
Metabolism: Hepatic.
Excretion: Elimination half-life: >3.5 hr (plasma); 18-36 hr (biological).
Should be taken with food.
Storage Conditions
Oral: Store at 2-8°C.
ATC Classification
H02AA02 - fludrocortisone ; Belongs to the class of mineralocorticoids. Used in systemic corticosteroid preparations.
Oral: Store at 2-8°C.
Available As
  • Fludrocortisone 100 mcg
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