Ferrous Fumarate

Indications
Oral
Iron-deficiency anaemia
Adult: Usual dose range: Up to 600 mg daily. May increase up to 1.2 g daily if necessary.
Child: As syrup containing 140 mg(45 mg iron)/5ml. Preterm neonate: 0.6-2.4 ml/kg daily; up to 6 yr: 2.5-5 ml bid.
Warnings / Precautions
Patients with intestinal strictures and diverticular disease. May worsen diarrhoea in patients with inflammatory bowel disease. May cause constipation and faecal impaction in elderly. Avoid prolonged admin (>6 mth) except in patients with continued bleeding, menorrhagia or repeated pregnancies. Not for routine use in treatment of haemolytic anaemia unless an iron-deficient state exists. Parenteral iron should not be used concurrently with oral iron treatment. Avoid use in patients receiving repeated blood tranfusions. Pregnancy.
Adverse Reactions
GI disturbance including constipation, diarrhoea, dark stools. Nausea and epi-gastric pain.
Overdose Reactions
Symptoms: Nausea, vomiting, abdominal pain, diarrhoea, haematemesis and rectal bleeding. Hypotension, coma and hepatocellular necrosis may occur later. Treatment: Empty stomach contents by gastric lavage within 1 hr of ingestion. In severe toxicity, IV desferrioxamine may be given. Whole bowel irrigation may also be considered in severe poisoning.
Drug Interactions
Oral absorption of iron may be increased when taken with ascorbic acid. May reduce the absorption of quinolones and tetracyclines when taken concurrently via the oral route. Concurrent admin with antacids may reduce the absorption of ferrous fumarate from the GI tract. May reduce the absorption of penicillamine in the gut when taken concurrently.
See Below for More ferrous fumarate Drug Interactions
Mechanism of Actions
Ferrous fumarate is an iron preparation that is used in the prevention and treatment of iron deficiency. The amount of elemental iron is 330 mg/g of ferrous fumarate.
Absorption: GI iron absorption depends on the amount of stored iron in the body; absorption is higher when stored iron is low.
Distribution: Ferrous iron passes through the GI mucosal cells, bind to transferrin and is then transported to the bone marrow and incorporated into haemoglobin.
Excretion: Mainly through the faeces and desquamation of cells e.g. skin, hair or GI mucosa.
Administration
Should be taken on an empty stomach. (Best taken on an empty stomach. May be taken w/ meals to reduce GI discomfort.)
ATC Classification
B03AA02 - ferrous fumarate ; Belongs to the class of oral iron bivalent preparations. Used in the treatment of anemia.
B03AD02 - ferrous fumarate ; Belongs to the class of iron in combination with folic acid. Used in the treatment of anemia.
Available As
  • Ferrous Fumarate 0.35 gm
  • Ferrous Fumarate 1 mg
  • Ferrous Fumarate 10 mg
  • Ferrous Fumarate 100 mg
  • Ferrous Fumarate 110 mg
  • Ferrous Fumarate 113.75 mg
  • Ferrous Fumarate 12 mg
  • Ferrous Fumarate 120 mg
  • Ferrous Fumarate IP 150 mg
  • Ferrous Fumarate 150 mg
  • Ferrous Fumarate 152 mg
  • Ferrous Fumarate 16 mg
  • Ferrous Fumarate 165 mg
  • Ferrous Fumarate 168 mg
  • Ferrous Fumarate 175 mg
  • Ferrous Fumarate 18 mg
  • Ferrous Fumarate 185 mg
  • Ferrous Fumarate IP 195 mg
  • Ferrous Fumarate 20 mg
  • Ferrous Fumarate 200 mcg
  • Ferrous Fumarate 200 mg
  • Ferrous Fumarate IP 200 mg
  • Ferrous Fumarate 240 mg
  • Ferrous Fumarate 25 mg
  • Ferrous Fumarate 250 mg
  • Ferrous Fumarate 260 mg
  • Ferrous Fumarate 3 mg
  • Ferrous Fumarate 30 mg
  • Ferrous Fumarate IP 30 mg
  • Ferrous Fumarate 30.42 mg
  • Ferrous Fumarate 30.5 mg
  • Ferrous Fumarate IP 300 mg
  • Ferrous Fumarate 300 mg
  • Ferrous Fumarate 304 mg
  • Ferrous Fumarate 308 mg
  • Ferrous Fumarate 325 mg
  • Ferrous Fumarate 33.3 mg
  • Ferrous Fumarate 330 mg
  • Ferrous Fumarate IP 350 mg
  • Ferrous Fumarate 350 mg
  • Ferrous Fumarate 36.5 mg
  • Ferrous Fumarate 360 mg
  • Ferrous Fumarate 4 mg
  • Ferrous Fumarate 40 mg
  • Ferrous Fumarate 400 mg
  • Ferrous Fumarate 45 mg
  • Ferrous Fumarate 5 mg
  • Ferrous Fumarate IP 50 mg
  • Ferrous Fumarate 50 mg
  • Ferrous Fumarate 500 mg
  • Ferrous Fumarate 55 mg
  • Ferrous Fumarate 60 mg
  • Ferrous Fumarate 61 mg
  • Ferrous Fumarate 7.76 mg
  • Ferrous Fumarate 75 mg
  • Ferrous Fumarate 8 mg
  • Ferrous Fumarate 800 mg
  • Ferrous Fumarate 9 mg
  • Ferrous Fumarate 90 mg
  • Ferrous Fumarate IP 90 mg
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