Etodolac

Indications
 Oral
Osteoarthritis
Adult: 600-1000 mg/day in divided doses adjusted according to response.
Max Dosage: 1200 mg daily.
Oral
Rheumatoid arthritis
Adult: 600-1000 mg/day in divided doses adjusted according to response.
Max Dosage: 1200 mg daily.
Oral
Acute pain
Adult: 200-400 mg every 6-8 hr. Max: 1 g/day.
Contraindications
 Peptic ulcer, hypersensitivity to etodolac/NSAIDs. Childn; pregnancy (3rd trimester) and lactation.
Warnings / Precautions
 CHF, dehydration, impaired renal, hepatic function, history of GI disease. Elderly, patients receiving anticoagulant.
Adverse Reactions
 GI disturbances; CNS effects; hypersensitivity reactions. Rash, pruritus; neuromuscular and skeletal weaknesses; blurred vision.
Potentially Fatal: Acute renal failure; blood disorder; nephrotoxicity; angioedema, arrhythmia, bone marrow suppression, CHF, dyspnoea, erythema multiforme, exfoliative dermatitis, hepatitis, hypertension, peripheral neuropathy, Stevens-Johnson syndrome, syncope, tachycardia, toxic amblyopia, toxic epidermal necrolysis, urticaria.
Drug Interactions
 Increased effect of warfarin, lithium, methotrexate, digoxin, cyclosporin, aspirin. Effect may be reduced with aspirin. Reduced effect of some diuretics and β-blockers. Alcohol enhances gastric mucosal irritation.
See Below for More etodolac Drug Interactions
Lab Interactions
 False-positive for urinary bilirubin and ketones. Increased bleeding time.
Food Interactions
 Peak serum levels and GI distress decreased when taken with food. Cat's claw, dong quai, evening primrose, feverfew, ginkgo, red clover, horse chestnut, green tea and ginseng enhance the antiplatelet effect.
Mechanism of Actions
 Etodolac is an NSAID derived from pyrano-indoleacetic acid, inhibits cyclooxygenase 2 (COX-2) resulting in decreased prostaglandin precursor formation.
Onset: Analgesic: 2-4 hrs.
Administration
 Should be taken with food. (Take w/ or immediately after meals.)
ATC Classification
 M01AB08 - etodolac ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.
Available As
  • Etodolac 200 mg
  • Etodolac 300 mg
  • Etodolac 400 mg
  • Etodolac 500 mg
  • Etodolac 600 mg

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