Ethionamide

Indications
 Oral
Tuberculosis, Leprosy
Adult: 15-20 mg/kg/day. Max: 1 g/day.
Child: Tuberculosis: 15-20 mg/kg/day, given in 2-3 divided doses. Max: 1 g/day.
Elderly:
Contraindications
 Hypersensitivity, severe liver disease, porphyria.
Warnings / Precautions
 Difficulty in managing DM. Monitor blood glucose, thyroid and visual function. Perform LFT before and during treatment. Caution in patients with psychiatric illness or depression. Pregnancy, lactation.
Adverse Reactions
 Anorexia, excessive salivation, metallic taste, nausea, vomiting, abdominal pain, diarrhoea. Peripheral and/or optic neuritis, psychiatric disturbances eg, depression, anxiety, psychosis, postural hypotension. Jaundice, hepatitis. Thrombocytopenia, skin rashes, stomatitis, gynaecomastia.
Drug Interactions
 May increase serum levels of isoniazid and potentiate the adverse effects of other antituberculous drugs when used concurrently. May cause psychotic reaction when taken with excessive ethanol.
Potentially Fatal: Increased incidence of hepatotoxicity with rifampicin. Increase CNS toxicity with cycloserine.
See Below for More ethionamide Drug Interactions
Mechanism of Actions
 Ethionamide inhibits peptide synthesis. It is active against mycobacteria species. Bacteriostatic against M.tuberculosis. Also active against atypical mycobacteria eg, M. kansasii, and some strains of M. avium complex, and M. leprae.
Absorption: Readily absorbed from the GIT (oral).
Distribution: Body tissues and fluids (wide), CSF (concentrations equiv to serum), crosses the placenta. Protein-binding: 30%
Metabolism: Extensive hepatic metabolism; converted to the active sulfide and some inactive metabolites.
Excretion: Via urine (<1% as unchanged); 2-3 hrs (elimination half-life).
Administration
 Should be taken with food. (Take at mealtimes.)
Storage Conditions
 Oral: Store at 25°C.
ATC Classification
 J04AD03 - ethionamide ; Belongs to the class of thiocarbamide derivatives. Used in the systemic treatment of tuberculosis.
Storage
 Oral: Store at 25°C.
Available As
  • Ethionamide 250 mg

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