Estrogens

Indications
 Oral
Moderate to severe vasomotor symptoms associated with menopause
Adult: 0.45 mg/day; may increase up to 1.25 mg/day; attempt to discontinue medication at 3-6-mth intervals.
Oral
Vulvular and vaginal atrophy
Adult: 0.3 mg/day.
Oral
Female hypogonadism
Adult: 0.3-0.625 mg/day given cyclically, may titrate dose in 6-12-mth intervals; add progestin treatment to maintain bone mineral density once skeletal maturity is achieved.
Oral
Female castration or primary ovarian failure
Adult: 1.25 mg/day given cyclically; adjust according to patient response. For maintenance, adjust to the lowest effective dose.
Oral
Palliative treatment of prostatic carcinoma
Adult: 1.25-2.5 mg 3 times/day.
Oral
Prophylaxis of osteoporosis in postmenopausal women
Adult: Initial: 0.3 mg/day, cyclically or daily, depending on patient's condition. Adjust dose based on bone mineral density and clinical response. Lowest effective dose should be used.
Parenteral
Abnormal uterine bleeding
Adult: 25 mg via IV/IM admin, may repeat in 6-12 hr if needed. Treatment should be followed by a low-dose oral contraceptive.
Contraindications
 Severe liver impairment; breast carcinoma; thromboembolic disorders; CV disease; undiagnosed vag bleeding; estrogen-dependent neoplasms; hypersensitivity; pregnancy.
Warnings / Precautions
 Asthma, epilepsy, migraine; heart or kidney dysfunction; CV disease; cerebrovascular disorders; diabetes, hypercalcaemia; gall bladder disease; porphyria. Childn. Lactation.
Adverse Reactions
 Abnormal bleeding; vomiting, nausea; tender breasts, wt gain, fluid retention; headache, depression. Males: Gynaecomastia, impotence.
Potentially Fatal: Unopposed replacement therapy in postmenopausal women associated with increased risk of endometrial and breast cancer.
Drug Interactions
 Rifampicin, barbiturates increase rate of metabolism.
Potentially Fatal: May reduce the efficacy of anticoagulants.
See Below for More estrogens Drug Interactions
Lab Interactions
 Interfere with tests for thyroid function and glucose tolerance.
Mechanism of Actions
 Estrogens modulate pituitary secretion of gonadotropins, leutinising hormones and follicle-stimulating hormones through -ve feedback mechanism, thus reducing elevated levels of hormones in postmenopausal women during oestrogen replacement therapy
Absorption: Absorbed from the intestines after removal of the sulfate group (oral).
Metabolism: Hepatic; undergoes enterohepatic recycling.
Excretion: Via the urine and faeces.
Storage Conditions
 Oral: Store at 25°C. Parenteral: Store at 2-8°C. To be used immediately after reconstitution.
ATC Classification
 G03C - ESTROGENS ; Used in estrogenic hormone preparations.
L02AA - Estrogens ; Used in endocrine therapy.
Storage
 Oral: Store at 25°C. Parenteral: Store at 2-8°C. To be used immediately after reconstitution.
Available As
  • Estrogens 0.3 mg
  • Estrogens 0.625 mg
  • Estrogens 1.25 mg
  • Estrogens 25 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Estrogens


    Estrogens Containing Brands

    We are Developing Our database, More results coming soon.

    Estrogens is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Estrogens

    We are Developing Our database, More results coming soon.