Erdosteine

Indications
 Oral
Mucolytic
Adult: 300 mg bid. Max duration: 10 days.
Contraindications
 Active peptic ulcer.
Warnings / Precautions
 Pregnancy, lactation.
Adverse Reactions
 Epigastralgia, nausea, vomiting, loose stools, spasmodic colitis, headache.
Mechanism of Actions
 Erdosteine contains two sulfhydryl groups, which are freed after metabolic transformation in the liver. The liberated sulfhydryl groups break the disulphide bonds, which hold the glycoprotein fibres of mucus together. This makes the bronchial secretions more fluid and enhances elimination.
Absorption: Rapid absorption after oral admin.
Distribution: Protein binding: 64.5%.
Metabolism: Undergoes 1st-pass metabolism to form an active metabolite, N-thiodiglycolyl-homocysteine.
Excretion: Elimination half-life: About 1.46 hr (erdosteine), and about 1.62 hr (metabolite). Mainly via the urine, as metabolites.
Storage Conditions
 Oral: Store below 25°C.
ATC Classification
 R05CB15 - erdosteine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
Storage
 Oral: Store below 25°C.
Available As
  • Erdosteine 300 mg

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