Ebastine

Indications	Oral Allergic conditions *Adult:* 10-20 mg once daily. *Child:* >6 yr: 5 mg once daily.
Contraindications	Hypersensitivity, cardiac arrhythmias.
Warnings / Precautions	Caution is advised when used in hepatic impairment, renal insufficiency, QTc interval prolongation. Pregnancy, lactation.
Adverse Reactions	Headache, dry mouth, drowsiness, pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea, insomnia.
Drug Interactions	Concomitant use of ketoconazole, itraconazole, clarithromycin or erythromycin may increase plasma levels of ebastine and cause QTc interval prolongation. See Below for More ebastine Drug Interactions
Mechanism of Actions	Ebastine, a piperidine derivative, is a long-acting, nonsedating, second-generation histamine receptor antagonist that binds preferentially to peripheral H₁ receptors. It is metabolised to active metabolite, carebastine. It has antihistaminic, antiallergic activity and prevents histamine-induced bronchoconstriction. It does not have significant sedative or antimuscarinic actions.
Administration	May be taken with or without food.
Storage Conditions	Oral: Store below 25°C.
ATC Classification	R06AX22 - ebastine ; Belongs to the class of other antihistamines for systemic use.
Storage	Oral: Store below 25°C.
Available As	Ebastine 10 mg Ebastine 20 mg Ebastine 5 mg

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