Dydrogesterone

Indications
 Oral
Endometriosis
Adult: 10 mg bid-tid cyclically or continuously.
Oral
Recurrent miscarriage
Adult: 10 mg bid given cyclically until conception, then continuously until wk 20 of pregnancy, after which dose may be gradually reduced.
Oral
Menstrual disorders
Adult: 10 mg bid in a cyclical regimen.
Oral
Threatened miscarriage
Adult: Initially, 40 mg followed by 10 mg or more every 8 hr, continued for a wk after symptoms are relieved. Reduce dose gradually after that unless symptoms return.
Oral
Infertility
Adult: 10 mg bid.
Oral
Endometrial protection during menopausal hormonal replacement therapy
Adult: 10 mg 1-2 times daily in a cyclical regimen or 5 mg daily.
Contraindications
 Hypersensitivity; pregnancy. Undiagnosed abnormal vag bleeding, thromboembolic disorders, history or existing cerebrovascular or coronary artery disease, missed or incomplete abortion, known or suspected carcinoma of the breast or genital organs, severe hepatic dysfunction, as a diagnostic test for pregnancy.
Warnings / Precautions
 Monitor closely for loss of vision, proptosis, diplopia, migraine, signs and symptoms of embolic disorders. CVD or renal impairment, epilepsy, asthma, other conditions which may be aggravated by fluid retention. Lactation.
Adverse Reactions
 Dizziness, nausea, headache, fatigue, emotional lability, irritability; abdominal pain and distention; muskuloskeletal pain.
Drug Interactions
 Carbamazepine, griseofulvin, phenobarbital, rifampicin enhances the clearance of progestogens.
See Below for More dydrogesterone Drug Interactions
Lab Interactions
 Altered serum-lipid profile and liver function tests.
Mechanism of Actions
 Dydrogesterone is a progestogen structurally related to progesterone. However, unlike progesterone, it does not induce an increase in temp nor inhibit ovulation and may be preferred over other progestational agents when contraceptive effect is not required. It does not have oestrogenic or androgenic properties.
Absorption: Absorbed following buccal, rectal, and vag administration; rapidly absorbed following (IM).
Metabolism: Hepatic: Extensive first-pass effect.
Excretion: Via urine (as sulfate and glucuronide conjugates).
Administration
 May be taken with or without food.
ATC Classification
 G03DB01 - dydrogesterone ; Belongs to the class of pregnadien derivative progestogens used in progestogenic hormone preparations.
Available As
  • Dydrogesterone 10 mg

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