Adult: 10 mg bid-tid cyclically or continuously.
Recurrent miscarriage
Adult: 10 mg bid given cyclically until conception, then continuously until wk 20 of pregnancy, after which dose may be gradually reduced.
Menstrual disorders
Adult: 10 mg bid in a cyclical regimen.
Threatened miscarriage
Adult: Initially, 40 mg followed by 10 mg or more every 8 hr, continued for a wk after symptoms are relieved. Reduce dose gradually after that unless symptoms return.
Adult: 10 mg bid.
Endometrial protection during menopausal hormonal replacement therapy
Adult: 10 mg 1-2 times daily in a cyclical regimen or 5 mg daily.
Hypersensitivity; pregnancy. Undiagnosed abnormal vag bleeding, thromboembolic disorders, history or existing cerebrovascular or coronary artery disease, missed or incomplete abortion, known or suspected carcinoma of the breast or genital organs, severe hepatic dysfunction, as a diagnostic test for pregnancy.
Warnings / Precautions
Monitor closely for loss of vision, proptosis, diplopia, migraine, signs and symptoms of embolic disorders. CVD or renal impairment, epilepsy, asthma, other conditions which may be aggravated by fluid retention. Lactation.
Adverse Reactions
Dizziness, nausea, headache, fatigue, emotional lability, irritability; abdominal pain and distention; muskuloskeletal pain.
Drug Interactions
Carbamazepine, griseofulvin, phenobarbital, rifampicin enhances the clearance of progestogens.
See Below for More dydrogesterone Drug Interactions
Lab Interactions
Altered serum-lipid profile and liver function tests.
Mechanism of Actions
Dydrogesterone is a progestogen structurally related to progesterone. However, unlike progesterone, it does not induce an increase in temp nor inhibit ovulation and may be preferred over other progestational agents when contraceptive effect is not required. It does not have oestrogenic or androgenic properties.
Absorption: Absorbed following buccal, rectal, and vag administration; rapidly absorbed following (IM).
Metabolism: Hepatic: Extensive first-pass effect.
Excretion: Via urine (as sulfate and glucuronide conjugates).
May be taken with or without food.
ATC Classification
G03DB01 - dydrogesterone ; Belongs to the class of pregnadien derivative progestogens used in progestogenic hormone preparations.
Available As
  • Dydrogesterone 10 mg
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