Hypersensitivity reactions
Adult: 25 mg every 4-6 hr. Max: 150 mg daily.
Adult: 25 mg given 30 minutes before retiring at night.
Severe liver disease; avoid alcohol; premature infants or full-term neonates.
Warnings / Precautions
May impair ability to drive and operate machinery. Angle-closure galucoma, urinary retention, prostatic hypertrophy or pyloroduodenal obstruction; epilepsy; hepatic impairment. Elderly. Lactation.
Adverse Reactions
Acute dystonic reactions and long-lasting impaired consciousness in child. CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, extrapyramidal effects, tremor, confusion, tinnitus, hypotension, hair loss.
Drug Interactions
Enhance effects of CNS depressants eg alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Atropine, TCAs, MAOIs. Can mask signs of ototoxicity caused by aminoglycosides.
See Below for More doxylamine Drug Interactions
Mechanism of Actions
Doxylamine is an antihistamine derived from monoethanolamine possessing antimuscarinic and pronounced sedative effects.
Absorption: Plasma concentrations peak 2-3 hr after oral admin.
Should be taken with food. (Take w/ food or milk.)
Storage Conditions
Oral: Store at 15-30°C.
ATC Classification
R06AA09 - doxylamine ; Belongs to the class of aminoalkyl ethers used as systemic antihistamines.
Oral: Store at 15-30°C.
Available As
  • Doxylamine Succinate 10 mg
  • Doxylamine 10 mg
  • Doxylamine Sulphate 10 mg
  • Doxylamine Succinate 100 mg
  • Doxylamine Succinate 20 mg
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