Dipyridamole

Indications
 Oral
Prophylaxis of thromboembolism following cardiac valve replacement
Adult: 300-600 mg/day in divided doses with an oral anticoagulant.
Child: 5 mg/kg/day in divided doses.
Oral
Secondary prophylaxis of stroke or transient ischaemic attack
Adult: As modified-release preparation: 200 mg bid, with or without aspirin.
Contraindications
 Hypersensitivity. Peptic ulcer.
Warnings / Precautions
 In patients with rapidly worsening angina, subvalvular aortic stenosis, haemodynamic instability associated with recent MI or coagulation disorders esp when given IV during myocardial imaging. Hypotension, unstable angina, aortic stenosis. Pregnancy and lactation. Safety and efficacy are not established in childn < 12 yrs.
Adverse Reactions
 GI disturbances, headache, dizziness, faintness, facial flushing, skin rash, liver dysfunction, angina. Large doses may lower BP.
Potentially Fatal: Risk of worsening angina and cardiac arrhythmias when given IV.
Overdose Reactions
 Symptoms: warm feeling, flushes, sweating, restlessness, weakness, dizziness, hypotension and tachycardia. Management: treatment is symptomatic. Empty stomach by gastric lavage. Haemodialysis unlikely to be useful.
Drug Interactions
 Aminophylline may reverse vasodilatation effect. Useful combination with aspirin in prevention of thromboembolism. Efficacy reduced by concurrent admin of antacids. Concurrent use may increase the cardiotoxic effects of adenosine.
Potentially Fatal: Potentiates effects of oral anticoagulants and antiarrhythmic agents.
See Below for More dipyridamole Drug Interactions
Mechanism of Actions
 Dipyridamole causes an accumulation of adenosine, adenine nucleotides and cAMP by inhibiting the activity of adenosine deaminase and phosphodiesterase thus inhibiting platelet aggregation and may cause vasodilation.
Absorption: Absorbed incompletely from the GIT (oral); peak plasma concentrations after 75 min.
Distribution: Protein-binding: Highly bound.
Metabolism: Hepatic; there is enterohepatic recirculation.
Excretion: Via bile (as glucuronides); 10-12 hrs (elimination half-life).
Administration
 Should be taken on an empty stomach. (Take on an empty stomach 1 hr before meals. May be taken w/ meals to reduce GI discomfort.)
Storage Conditions
 Oral: Store below 25°C.
ATC Classification
 B01AC07 - dipyridamole ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Storage
 Oral: Store below 25°C.
Available As
  • Dipyridamole 100 mg
  • Dipyridamole 200 mg
  • Dipyridamole 25 mg
  • Dipyridamole 75 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Dipyridamole


    Dipyridamole Containing Brands

    We are Developing Our database, More results coming soon.

    Dipyridamole is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Dipyridamole

    We are Developing Our database, More results coming soon.