Dimethindene Maleate

Indications	Oral Allergic conditions *Adult:* As maleate: 1-2 mg tid. Topical/Cutaneous Pruritic skin disorders *Adult:* As 0.1% gel/lotion: Use as directed.
Contraindications	Neonates, infants, urinary retention, paralytic ileus.
Warnings / Precautions	Elderly, closed-angle glaucoma, benign prostatic hyperplasia, driving, epilepsy, GI tract obstruction. Pregnancy and lactation.
Adverse Reactions	CNS depression, paradoxical CNS excitation, dryness of mouth, thickened resp mucus, urinary retention, constipation, tachycardia and arrhythmias, blurring of vision, GI upsets, blood dyscrasias. Topical application: Sensitisation.
Drug Interactions	Masks ototoxicity produced by aminoglycosides and antibiotics. Potentiate CNS depressant actions of alcohol, barbiturates, sedatives, opioid analgesics and neuroleptics. May block the effects of betahistine. QT prolongation may occur when used with mefloquine. May cause increased sedative effects when used with thalidomide. Potentially Fatal: Additive antimuscarinic action with MAOIs, atropine and TCAs. See Below for More dimethindene Drug Interactions
Mechanism of Actions	Dimethindene is an alkylamine derivative. It is mildy sedative and have mast-cell stabilising properties. It is also a potent H₁-antagonist and possesses significant sedative actions. May cause paradoxical stimulation of CNS esp in children.
Available As	Dimethindene Maleate 1 mg Dimethendine 10 mg Dimethindene Maleate 2.5 mg

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