Dimenhydrinate

Indications
 Oral
Treatment and prophylaxis of motion sickness
Adult: 50-100 mg 3-4 times daily. For prevention of motion sickness, 1st dose to be given at least 30 minutes before traveling.
Child: 2-6 yr: 12.5-25 mg; 6-12 yr: 25-50 mg; Doses can be repeated every 6-8 hr. Max: 75 mg daily (2-6 yr) and 150 mg daily (6-12 yr).
Oral
Nausea and vertigo caused by Meniere's disease
Adult: 50-100 mg 3-4 times daily. For prevention of motion sickness, 1st dose to be given at least 30 minutes before traveling.
Child: 2-6 yr: 12.5-25 mg; 6-12 yr: 25-50 mg; Doses can be repeated every 6-8 hr. Max: 75 mg daily (2-6 yr) and 150 mg daily (6-12 yr).
Parenteral
Treatment and prophylaxis of motion sickness
Adult: 50 mg in a 5% solution given IM or 0.5% slow IV inj given over 2 min.
Child: 1.25 mg/kg IM or slow IV inj 4 times daily. Max: 300 mg/day.
Parenteral
Nausea and vertigo caused by Meniere's disease
Adult: 50 mg in a 5% solution given IM or 0.5% slow IV inj given over 2 min.
Child: 1.25 mg/kg IM or slow IV inj 4 times daily. Max: 300 mg/day.
Contraindications
 Hypersensitivity to dimenhydrinate, porphyria. Neonates. Lactation.
Warnings / Precautions
 Angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction, epilepsy. Elderly. Tasks requiring mental alertness. Pregnancy.
Adverse Reactions
 Sedation, dry mouth, thickened respiratory tract secretions, tightness of chest, bradycardia followed by tachycardia and arrhythmias, blurred vision, urinary retention, constipation, GI disturbance, blood dyscrasias. Paradoxical CNS stimulation may occur in children and occasionally in adults.
Overdose Reactions
 Symptoms in children: dilated pupils, flushed face, excitation, hallucinations, confusion, ataxia, intermittent clonic convulsions, coma, cardiorespiratory collapse, and death. Symptoms may manifest up to 2 hr after ingestion and death may occur within 18 hr. Symptoms in adult: Difficulty in speech and swallowing, psychosis, sedation then CNS excitation, leading to a cycle of CNS excitation, seizures and postictal depression. Mangagement: Treatment is symptomatic and supportive. Gastric lavage may be performed with an endotracheal tube with cuff inflated in place to prevent aspiration of gastric contents. Keep patient quiet to reduce CNS stimulation. Convulsions may be treated with diazepam in adults and phenobarbital in children.
Drug Interactions
 Physically incompatible with aminophylline, hydrocortisone, phenothiazines and some barbiturates in solution.
Potentially Fatal: Potentiates the sedative effects of CNS depressants including alcohol, barbiturates, opioid analgesics, sedatives and neuroleptics. MAOIs, atropine, TCAs enhance antimuscarinic effect. Masks ototoxicity produced by aminoglycoside antibiotics.
See Below for More dimenhydrinate Drug Interactions
Lab Interactions
 May interfere with plasma theophylline estimation by radioimmunoassay.
Mechanism of Actions
 Dimenhydrinate is an antihistamine which also has antimuscarinic and central sedative action. It also exerts a depressant action on hyperstimulated labyrinthine function.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store below 25°C. Parenteral: Store below 25°C.
Storage
 Oral: Store below 25°C. Parenteral: Store below 25°C.
Available As
  • Dimenhydrinate 15.625 mg
  • Dimenhydrinate 15.63 mg
  • Dimenhydrinate 50 mg

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