Diloxanide

Indications
Oral
Intestinal amoebiasis
Adult: 500 mg tid for 10 days. May repeat course if needed.
Child: >25 kg: 20 mg/kg daily in 3 divided doses for 10 days, repeated if necessary.
Warnings / Precautions
Pregnancy and lactation.
Adverse Reactions
Flatulence, anorexia, nausea, vomiting, pruritus, urticaria.
Mechanism of Actions
Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.
Absorption: Absorbed from the GI tract (oral).
Metabolism: Rapidly hydrolysed prior to absorption.
Excretion: Via faeces (<10% of dose).
Storage Conditions
Oral: Store at 25°C.
ATC Classification
P01AC01 - diloxanide ; Belongs to the class of dichloroacetamide derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.
Storage
Oral: Store at 25°C.
Available As
  • Diloxanide Furoate 125 mg
  • Diloxanide 125 mg
  • Diloxanide Furoate 250 mg
  • Diloxanide 250 mg
  • Diloxanide Furoate 375 mg
  • Diloxanide Furoate 500 mg
  • Diloxanide 500 mg
  • Diloxanide Furoate 62.5 mg
  • Diloxanide Furoate 750 mg
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