Diethylcarbamazine

Indications
Oral
Filariasis
Adult: Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections.
Oral
Toxocariasis
Adult: Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections.
Oral
Loiasis
Adult: Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections.
Oral
Prophylaxis of loiasis
Adult: 300 mg wkly.
Contraindications
Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease.
Warnings / Precautions
Patients with poor health.
Adverse Reactions
Fever, headache, vomiting, dizziness, drowsiness, nausea, chills.
Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage.
Mechanism of Actions
Diethylcarbamazine is an anthelmintic that is used in the treatment of lymphatic filariasis. It is active against the microfilariae and adult worms of W. bancrofti, B. malayi, B. timori and Loa loa but only against the microfilariae of O. volvulus. It is also used in treatment of toxocariasis. Repeated courses may be necessary.
Absorption: Readily absorbed from the GI tract (oral); skin (topical); conjunctiva (optical).
Distribution: Widely distributed in tissues.
Excretion: Urine (as unchanged drug and N-oxide metabolite).
Storage Conditions
Oral: Store below 30°C.
ATC Classification
P02CB02 - diethylcarbamazine ; Belongs to the class of piperazine and derivatives agents. Used as antinematodal.
Storage
Oral: Store below 30°C.
Available As
  • Diethylcarbamazine 100 mg
  • Diethylcarbamazine 120 mg
  • Diethylcarbamazine 150 mg
  • Diethylcarbamazine 300 mg
  • Diethylcarbamazine 50 mg
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