Indications |
Oral Filariasis Adult: Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections. Oral Toxocariasis Adult: Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections. Oral Loiasis Adult: Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections. Oral Prophylaxis of loiasis Adult: 300 mg wkly. |
Contraindications |
Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease. |
Warnings / Precautions |
Patients with poor health. |
Adverse Reactions |
Fever, headache, vomiting, dizziness, drowsiness, nausea, chills. Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage. |
Mechanism of Actions |
Diethylcarbamazine is an anthelmintic that is used in the treatment of lymphatic filariasis. It is active against the microfilariae and adult worms of W. bancrofti, B. malayi, B. timori and Loa loa but only against the microfilariae of O. volvulus. It is also used in treatment of toxocariasis. Repeated courses may be necessary. Absorption: Readily absorbed from the GI tract (oral); skin (topical); conjunctiva (optical). Distribution: Widely distributed in tissues. Excretion: Urine (as unchanged drug and N-oxide metabolite). |
Storage Conditions |
Oral: Store below 30°C. |
ATC Classification |
P02CB02 - diethylcarbamazine ; Belongs to the class of piperazine and derivatives agents. Used as antinematodal. |
Storage |
Oral: Store below 30°C. |
Available As |
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Diethylcarbamazine
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Diethylcarbamazine Containing Brands
Diethylcarbamazine is used in following diseases
Drug - Drug Interactions of Diethylcarbamazine
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