Dexibuprofen

Indications
 Oral
Pain and inflammation associated with musculoskeletal and joint disorders, Dysmenorrhoea
Adult: 600-900 mg daily in 2-3 divided doses. May increase to 1200 mg daily for patients with acute conditions or exacerbations.
Max Dosage: 400 mg/dose and 1200 mg/day.
Renal impairment: Dose reduction is recommended.
Hepatic impairment: Dose reduction is recommended.

Special Populations: Should not be used in patients with severe hepatic and renal impairment. In case of mild to moderate hepatic and renal dysfunction, start therapy at reduced dose and monitor patient closely.
Contraindications
 Hypersensitivity to aspirin or NSAIDs; active or suspected GI ulcer or history of recurrent GI ulcer; GI bleeding or other active bleedings or bleeding disorders; active Crohn's disease or ulcerative colitis; haemorrhagic diasthesis and other coagulation disorders, or patients receiving anticoagulant therapy; severe heart failure, renal or hepatic impairment; child <18 yrs; pregnancy (third trimester).
Warnings / Precautions
 History of bronchial asthma; renal or hepatic disorders; bleeding disorders; CV disease; elderly; lactation.
Adverse Reactions
 GI bleeding, heartburn, epigastric pain; dyspepsia, peptic ulcer; nausea, vomiting, diarrhoea; jaundice, hepatitis; rash; thrombocytopaenia; visual disturbances; tinnitus; depression; fatigue, headache, dizziness, vertigo.
Drug Interactions
 Avoid concomitant use with anticoagulants, other NSAIDs and salicylates. Increases risk of methotrexate and lithium toxicity.
See Below for More dexibuprofen Drug Interactions
Food Interactions
 Decreased peak serum levels if taken with food but no effect on the extent of absorption.
Mechanism of Actions
 Dexibuprofen is a NSAID. It acts by inhibition of cyclo-oxygenase, which is involved in prostaglandin synthesis.
Storage Conditions
 Oral: Store at or below 25°C.
ATC Classification
 M01AE14 - dexibuprofen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.
Storage
 Oral: Store at or below 25°C.
Available As
  • Dexibuprofen 200 mg
  • Dexibuprofen 300 mg
  • Dexibuprofen 400 mg

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