Oral contraception
Adult: 75 mcg daily when used alone. For monophasic combined oral contraceptives: Typically, 150 mcg daily; for triphasic combined oral contraceptives: 50-150 mcg daily.
Pregnancy, undiagnosed vaginal bleeding, severe arterial disease; liver adenoma, porphyria; after evacuation of hydatidiform mole; history of breast cancer.
Warnings / Precautions
Heart disease, sex-steroid dependent cancer, past ectopic pregnancy, malabsorption syndromes, functional ovarian cysts, active liver disease, recurrent cholestatic jaundice, history of jaundice in pregnancy, history of CV or renal impairment, DM, asthma, epilepsy, migraine, depression and thromboembolism; lactation.
Adverse Reactions
Menstrual irregularities; nausea, vomiting, headache, dizziness, breast discomfort, gynecomastia, depression, skin disorders, disturbance of appetite, wt changes, fluid retention, oedema, changes in libido, cholestatic jaundice, hair loss or hirsutism.
Drug Interactions
Reduced efficacy with enzyme-inducing drugs; aminoglutethimide. May inhibit ciclosporin metabolism.
See Below for More desogestrel Drug Interactions
Mechanism of Actions
Desogestrel is a progestogen structurally related to levonorgestrel that has been shown to reliably inhibit ovulation.
Distribution: 32% of 3-keto-desogestrel is bound to sex hormone binding globulin and 66% to albumin.
Metabolism: After oral admin, it undergoes oxidative transformation in the intestinal mucosa and liver to form its active metabolite, 3-keto-desogestrel.
ATC Classification
G03AC09 - desogestrel ; Belongs to the class of progestogens. Used as systemic contraceptives.
Available As
  • Desogestrel 0.075 mg
  • Desogestrel 0.15 mg
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