Demeclocycline

Indications
 Oral
Susceptible infections
Adult: 150 mg four times daily or 300 mg bid.
Child: >8 yr: 7-13 mg/kg daily divided every 6-12 hr.
Renal impairment: Dose adjustments or increase in frequency may be needed.
Hepatic impairment: Dose adjustments or increase in frequency may be needed. Max: 1 g daily.
Oral
Atypical pneumonia
Adult: 300 mg tid.
Renal impairment: Dose adjustments or increase in frequency may be needed.
Hepatic impairment: Dose adjustments or increase in frequency may be needed. Max: 1 g daily.
Oral
Chronic hyponatraemia associated with syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Adult: Initial dose: 900-1200 mg/day in divided doses. Maintenance dose: 600-900 mg/day in divided doses.
Renal impairment: Dose adjustments or increase in frequency may be needed.
Hepatic impairment: Dose adjustments or increase in frequency may be needed. Max: 1 g daily.

Special Populations: Patients with liver disease should not be given >1 g daily.
Contraindications
 Hypersensitivity. Pregnancy and lactation.
Warnings / Precautions
 Children <12 yr; SLE; renal or hepatic disease.
Adverse Reactions
 Photosensitivity. Reversible nephrogenic diabetes insipidus. Permanent staining of teeth; nausea; rash; GI upsets; dysphagia; enterocolitis; anogenital inflammation (moniliasis). Hypersensitivity; haemolytic anaemia, thrombocytopenia, neutropenia and eosinophilia; raised blood urea and liver enzymes.
Potentially Fatal: Anaphylaxis (rare).
Overdose Reactions
 Treatment is symptomatic and supportive. Haemodialysis or peritoneal dialysis unlikely to be helpful.
Drug Interactions
 Antacids, milk, calcium, magnesium and iron preparations reduce absorption. Diuresis induced by amiloride and metolazone may be enhanced. May reduce efficacy of oral contraceptives when used concurrently.
See Below for More demeclocycline Drug Interactions
Lab Interactions
 May interfere with urinary urobilinogen estimation.
Food Interactions
 Milk and milk products reduce absorption.
Mechanism of Actions
 Demeclocycline binds to 30s ribosomal subunit causing an inhibition in protein synthesis of susceptible bacteria.
Absorption: 60-80% of an oral dose is absorbed from the GI tract.
Excretion: Elimination half-life: about 12 hr.
Administration
 Should be taken on an empty stomach. (Take w/ a full glass of water on an empty stomach at least 1 hr before or 2 hr after meals.)
Storage Conditions
 Oral: Store below 25°C.
ATC Classification
 D06AA01 - demeclocycline ; Belongs to the class of topical tetracycline and derivatives agents used in the treatment of dermatological diseases.
J01AA01 - demeclocycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
Storage
 Oral: Store below 25°C.
Available As
  • Demeclocycline 150 mg
  • Demeclocycline 300 mg

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