Deflazacort

Indications
Oral
Allergic and inflammatory disorders
Adult: Initially, up to 120 mg daily. Maintenance: 3-18 mg/day.
Child: 0.25-1.5 mg/kg/day given on alternate days.
Hepatic impairment: Dose reductions may be needed.
Contraindications
Systemic infection; live virus vaccines in those receiving immunosuppressive doses.
Warnings / Precautions
Adrenal suppression and infection, child, adolescents, elderly, history of TB and steroid myopathy, hypertension, recent MI, CHF, liver failure, renal impairment, DM and glaucoma (including family history), osteoporosis, corneal perforation, severe affective disorders, epilepsy, peptic ulcer, hypothyroidism, pregnancy and lactation.
Adverse Reactions
GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances; susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent MI, thromboembolism.
Drug Interactions
Antacids, ACE inhibitors, acetazolamide, adrenergic neuron blockers, antidiabetics, aspirin, barbiturate, β-blockers, calcium-channel blockers, carbamazepine, carbenoxolone, cardiac glycosides, clonidine, coumarins, diazoxide, diuretics, erythromycin, hydralazine, ketoconazole, methotrexate, methyldopa, mifepristone, minoxidil, moxonidine, nitrates, nitroprusside, NSAIDs, oestrogens, phenytoin, primidone, rifamycins, ritonavir, somatropin, β2 sympathomimetics, theophylline, vaccines.
See Below for More deflazacort Drug Interactions
Food Interactions
Salad and vegetable diet including alcohol may affect anticoagulant control.
Mechanism of Actions
Deflazacort, derived from prednisolone, is a corticosteroid with mainly glucocorticoid activity. An anti-inflammatory dose of 6 mg deflazacort is equiv to 5 mg prednisolone.
ATC Classification
H02AB13 - deflazacort ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
Available As
  • Deflazacort 1 mg
  • Deflazacort 12 mg
  • Deflazacort 16 mg
  • Deflazacort 18 mg
  • Deflazacort 24 mg
  • Deflazacort 30 mg
  • Deflazacort 4 mg
  • Deflazacort 6 mg
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