Adult: 200-800 mg daily in 2 divided doses adjusted according to response, for 3-6 mth or if necessary, up to 9 mth.
Benign breast disorders
Adult: Initially, 100-400 mg daily in 2 divided doses adjusted according to response and continued for 3-6 mth.
Adult: Male adolescents: Initially, 200 mg daily, may increase to 400 mg daily after 2 mth if no response occurs; adult men: Initial: 400 mg daily in up to 4 divided doses. Usual treatment duration: 6 mth.
Child: Male adolescents: Initially, 200 mg daily increased to 400 mg after 2 mth if no response occurs. Treatment usually up to 6 months.
Hereditary angioedema
Adult: Initially, 200 mg bid-tid reduced thereafter according to patient's response.
Preoperative thinning of the endometrium
Adult: 400-800 mg daily, in up to 4 divided doses for 3-6 wk.
Adult: 200 mg once daily. Review treatment 3 mth later.
Hypersensitivity, pregnancy, lactation, porphyria, thromboembolic disorders; undiagnosed genital bleeding, markedly impaired renal, cardiac or hepatic dysfunction.
Warnings / Precautions
Epilepsy, migraine; cardiac, hepatic, renal disorders. Severe hypertension, diabetes, polycythaemia, history of thrombosis; children.
Adverse Reactions
Oedema, wt gain, sweating, acne, hirsutism, flushing, oily skin or hair, deepening of the voice, clitoral hypertrophy, amenorrhoea, hepatic dysfunction, CNS or GI disturbances, benign intracranial hypertension, reduction in breast size, visual disturbances, elevated LFT values.
Potentially Fatal: Thromboembolic events and fatal strokes have been reported.
Drug Interactions
Increased serum levels of ciclosporin, warfarin, carbamazepine and tacrolimus.
Potentially Fatal: Increased incidence of insulin resistance in diabetic patients.
See Below for More danazol Drug Interactions
Food Interactions
Increased conc with high fat meal.
Mechanism of Actions
Danazol suppresses the pituitary-ovarian axis by reducing the release of follicle-stimulating hormone and luteinizing hormone. This causes the regression and atrophy of endometrial tissue, decreases growth rate of abnormal breast tissue and reduces attacks in hereditary angioedema.
Onset: Approximately 4 wk.
Absorption: Absorbed from the GI tract (oral); absorption increases if taken with food.
Metabolism: Hepatic (extensive); converted to 2-hydroxymethylethisterone.
Excretion: Via the urine.
May be taken with or without food. (Take consistently either always w/ or always w/o meals.)
ATC Classification
G03XA01 - danazol ; Belongs to the class of antigonadotropins and similar agents.
Available As
  • Danazol 100 mg
  • Danazol 200 mg
  • Danazol 50 mg
  • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Danazol

    Danazol Containing Brands

    We are Developing Our database, More results coming soon.

    Danazol is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Danazol

    We are Developing Our database, More results coming soon.