Danazol

Indications
 Oral
Endometriosis
Adult: 200-800 mg daily in 2 divided doses adjusted according to response, for 3-6 mth or if necessary, up to 9 mth.
Oral
Benign breast disorders
Adult: Initially, 100-400 mg daily in 2 divided doses adjusted according to response and continued for 3-6 mth.
Oral
Gynaecomastia
Adult: Male adolescents: Initially, 200 mg daily, may increase to 400 mg daily after 2 mth if no response occurs; adult men: Initial: 400 mg daily in up to 4 divided doses. Usual treatment duration: 6 mth.
Child: Male adolescents: Initially, 200 mg daily increased to 400 mg after 2 mth if no response occurs. Treatment usually up to 6 months.
Oral
Hereditary angioedema
Adult: Initially, 200 mg bid-tid reduced thereafter according to patient's response.
Oral
Preoperative thinning of the endometrium
Adult: 400-800 mg daily, in up to 4 divided doses for 3-6 wk.
Oral
Menorrhagia
Adult: 200 mg once daily. Review treatment 3 mth later.
Contraindications
 Hypersensitivity, pregnancy, lactation, porphyria, thromboembolic disorders; undiagnosed genital bleeding, markedly impaired renal, cardiac or hepatic dysfunction.
Warnings / Precautions
 Epilepsy, migraine; cardiac, hepatic, renal disorders. Severe hypertension, diabetes, polycythaemia, history of thrombosis; children.
Adverse Reactions
 Oedema, wt gain, sweating, acne, hirsutism, flushing, oily skin or hair, deepening of the voice, clitoral hypertrophy, amenorrhoea, hepatic dysfunction, CNS or GI disturbances, benign intracranial hypertension, reduction in breast size, visual disturbances, elevated LFT values.
Potentially Fatal: Thromboembolic events and fatal strokes have been reported.
Drug Interactions
 Increased serum levels of ciclosporin, warfarin, carbamazepine and tacrolimus.
Potentially Fatal: Increased incidence of insulin resistance in diabetic patients.
See Below for More danazol Drug Interactions
Food Interactions
 Increased conc with high fat meal.
Mechanism of Actions
 Danazol suppresses the pituitary-ovarian axis by reducing the release of follicle-stimulating hormone and luteinizing hormone. This causes the regression and atrophy of endometrial tissue, decreases growth rate of abnormal breast tissue and reduces attacks in hereditary angioedema.
Onset: Approximately 4 wk.
Absorption: Absorbed from the GI tract (oral); absorption increases if taken with food.
Metabolism: Hepatic (extensive); converted to 2-hydroxymethylethisterone.
Excretion: Via the urine.
Administration
 May be taken with or without food. (Take consistently either always w/ or always w/o meals.)
ATC Classification
 G03XA01 - danazol ; Belongs to the class of antigonadotropins and similar agents.
Available As
  • Danazol 100 mg
  • Danazol 200 mg
  • Danazol 50 mg

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