Cyclizine

Indications
 Oral
Nausea and vomiting
Adult: As hydrochloride: 50 mg up to tid, up to 200 mg/day. For prevention of motion sickness, 1st dose should be given 30 min before travelling.
Child: 6-12 yr: As hydrochloride: 25 mg up to tid. For prevention of motion sickness, 1st dose should be given 30 min before travelling.
Renal impairment: Dose reductions may be needed.
Hepatic impairment: Avoid in severe liver disease.
Parenteral
Treatment and prophylaxis of motion sickness
Adult: As lactate: 50 mg IV/IM every 4-6 hr. 1st dose should be given 30 min before travelling.
Child: As lactate: 25 mg IV/IM up to tid. For prevention of motion sickness, 1st dose should be given 30 min before travelling.
Renal impairment: Dose reductions may be needed.
Hepatic impairment: Avoid in severe liver disease.
Parenteral
Prophylaxis of postoperative nausea and vomiting
Adult: As lactate: 50 mg up to tid, may be given via IV or IM admin. 1st dose should be given 20 min before anticipated end of surgery. Max: 200 mg/24 hr.
Child: 6-12 yr: As lactate: 25 mg up to tid, may be given via IV or IM admin. 1st dose should be given 20 min before anticipated end of surgery. Max: 50 mg tid.
Renal impairment: Dose reductions may be needed.
Hepatic impairment: Avoid in severe liver disease.

Special Populations: Prevention of motion sickness: Give 30 min before traveling.

Incompatibility: Cyclizine lactate may be incompatible with oxytetracycline hydrochloride, chlortetracycline hydrochloride, benzylpenicillin and solutions with a pH ≥6.8.
Incompatibility: Cyclizine lactate may be incompatible with oxytetracycline hydrochloride, chlortetracycline hydrochloride, benzylpenicillin and solutions with a pH ≥6.8.
Contraindications
 Premature or full-term neonates.
Warnings / Precautions
 Angle closure glaucoma; urinary retention; prostatic hypertrophy; pyloroduodenal obstruction; epilepsy, severe CV disorders; known or suspected QT interval prolongation; hypokalaemia or other electrolyte imbalances; asthma; hepatic impairment. May impair ability to drive or operate machinery. Tolerance with prolonged use. Broken or eczematous skin (topical use). Pregnancy and lactation. Elderly. Children <6 yr. Dependence.
Adverse Reactions
 CNS depression e.g. drowsiness to deep sleep, lassitude, dizziness and incoordination. Headache, psychomotor impairment, dry mouth, thickening of mucous secretions, blurred vision, difficult or painful urination, constipation and increased gastric reflux. Occasionally, GI disturbances, palpitations and arrhythmias. Rashes and hypersensitivity reactions. Blood dyscrasias (rare). Convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, sleep disturbances, tinnitus, hypotension and hair loss.
Overdose Reactions
 Dry mouth, blurred vision, tachycardia, urinary retention, drowsiness, dizziness, inco-ordination, ataxia, weakness, hyperexcitability, disorientation, impaired judgement, hallucinations, hyperkinesia, extrapyramidal motor disturbances, convulsions, hyperpyrexia and respiratory depression. Gastric lavage followed by supportive measures for respiration and circulation.
Drug Interactions
 Enhanced sedative effects of alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, antipsychotics. Additive antimuscarinic actions with other antimuscarinic drugs and some antidepressants (TCAs and MAOIs). May mask ototoxicity symptoms caused by aminoglycoside antibiotics.
See Below for More cyclizine Drug Interactions
Mechanism of Actions
 Cyclizine is a sedative antihistamine with antimuscarinic activity.
Onset: Within 2 hr upon GI absorption.
Duration: Approximately 4 hr.
Absorption: Absorbed from the GI tract.
Metabolism: Hepatically metabolised to relatively inactive metabolite.
Excretion: Plasma elimination half-lives of 20 hr.
ATC Classification
 R06AE03 - cyclizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.
Available As
  • Cyclizine 50 mg

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