Indications |
Oral Prophylaxis of thromboembolic disorders Adult: 75 mg once daily.
Oral Acute coronary syndrome Adult: For ST-elevation myocardial infarction: In combination with aspirin: 75 mg once daily. Patients ≤75 yr old may be given a loading dose of 300 mg. Continue treatment for up to 28 days. For unstable angina, non-ST-elevation myocardial infarction: Initial: 300 mg loading dose, followed by 75 mg once daily (with aspirin 75-325 mg once daily). |
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Contraindications |
Hypersensitivity. Active pathological bleeding. admin within 7 days after MI and ischaemic stroke, coagulation disorders. Lactation. | ||||
Warnings / Precautions |
Patients at risk of increased bleeding from trauma, surgery, or other pathological conditions; ulcer; renal and hepatic impairment; history of bleeding or haemostatic disorders. Pregnancy. | ||||
Adverse Reactions |
Dyspepsia, abdominal pain, nausea, vomiting, flatulence, constipation, gastritis, gastric and duodenal ulcers. GI upset, diarrhoea, paraesthesia, vertigo, headache, dizziness, pruritus and rashes. Potentially Fatal: Bleeding disorders including GI and intracranial haemorrhage. Blood dyscrasias. |
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Overdose Reactions |
Prolonged bleeding time and subsequent bleeding complications. If quick reversal is required, platelet transfusion may be considered. | ||||
Drug Interactions |
Co-admin with NSAIDs may increase the risk of stomach and intestinal bleeding. High-dose clopidogrel may lead to increased warfarin levels thus increasing the risk of bleeding. High-dose clopidogrel may also inhibit P450 (2C9), thus interfering with the metabolism of phenytoin, tamoxifen, torasemide, fluvastatin and some NSAIDs. Avoid concurrent use of drugs that inhibit CYP2C19, including omeprazole, esomeprazole, cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine and ticlopidine. See Below for More clopidogrel Drug Interactions |
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Mechanism of Actions |
Clopidogrel inhibits adenosine diphosphate (ADP) from binding to its receptor sites on the platelets and subsequent activation of glycoprotein GP IIb/IIIa complex thus preventing fibrinogen binding, platelet adhesion and aggregation. Absorption: Rapidly but incompletely absorbed from the GI tract (oral). Distribution: Protein-binding: Extensive. Metabolism: Hepatic: Extensive; converted to inactive carboxylic acid derivative and thiol derivative (active). Excretion: Via urine and faeces (as metabolites and unchanged drug). |
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Administration |
May be taken with or without food. |
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Storage Conditions |
Oral: Store at 25°C. | ||||
ATC Classification |
B01AC04 - clopidogrel ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis. | ||||
Storage |
Oral: Store at 25°C. | ||||
Available As |
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Clopidogrel
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Clopidogrel Containing Brands
Clopidogrel is used in following diseases
Drug - Drug Interactions of Clopidogrel
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