Clobetasone

Indications
 Ophthalmic
Inflammatory eye disorders
Adult: As eye drops containing 0.1%.
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: Use as 0.05% cream or ointment to be applied thinly once or bid on affected areas.
Contraindications
 Pregnancy (in high doses). Presence of acute infections. Treatment of rosacea; leg ulcers; acne vulgaris; widespread plaque psoriasis. Child <1 yr.
Warnings / Precautions
 May be absorbed in sufficient amounts to cause systemic effects when applied topically to large areas, broken skin or under occlusive dressings. Peptic ulcer, osteoporosis, psychoses or severe psychoneuroses. Not to be used indiscriminately for pruritus. CHF or hypertension. Diabetes mellitus, epilepsy, glaucoma, infectious diseases, ocular herpes simplex, chronic renal failure and uraemia. Active or doubtfully quiescent tuberculosis. Local treatment of eye disorders. Elderly. Prolonged use on the face.
Adverse Reactions
 Delayed wound healing. Corneal ulcers, raised IOP and reduced visual function (topical application). Na and water retention. Increased excretion of potassium. Ca and phosphorus mobilization with osteoporosis and spontaneous fractures. Increased insulin requirements of diabetics. Increased liability to infection. Infections may be masked. Acute adrenal insufficiency. Growth retardation in child. Cushingoid symptoms. Amenorrhoea, hyperhidrosis, skin thinning, CNS effects, intracranial hypertension, acute pancreatitis, aseptic necrosis of bone.
Drug Interactions
 Live vaccines. Barbiturates, carbamazepine, phenytoin, primidone or rifampicin; thiazide or furosemide. NSAIDs. Anticoagulants. Salicylates. Antimuscarinics.
See Below for More clobetasone Drug Interactions
Mechanism of Actions
 Clobetasone is a corticosteroid with glucocorticoid activity for the treatment of various skin disorders.
ATC Classification
 D07AB01 - clobetasone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
S01BA09 - clobetasone ; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.
Available As
  • Clobetasone 17-butyrate 0.05%
  • Clobetasone Butyrate 0.05%
  • Clobetasone 0.05%
  • Clobetasone 17-butyrate 0.05% w/w
  • Clobetasone Butyrate 0.05% w/w
  • Clobetasone 0.05% w/w
  • Clobetasone Butyrate 0.1% w/w

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