Cilnidipine

Indications
 Oral
Hypertension
Adult: 5-10 mg once daily, increase to 20 mg once daily if necessary.
Contraindications
 Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis.
Warnings / Precautions
 Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischemic pain following administration. Pregnancy, lactation.
Adverse Reactions
 Dizziness; flushing; headache; hypotension; peripheral oedema; tachycardia; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression; ischaemic chest pain; cerebral or myocardial ischaemia; transient blindness; rashes; fever; abnormal liver function; gingival hyperplasia; myalgia; tremor; impotence.
Drug Interactions
 Other antihypertensives; aldesleukin; antipsychotics that cause hypotension; may modify insulin and glucose responses; quinidine; carbamazepine; phenytoin; rifampicin; cimetidine; erythromycin.
See Below for More cilnidipine Drug Interactions
Lab Interactions
 Falsely elevated spectrophotometric values of urinary vanillylmandelic acid.
Mechanism of Actions
 Cilnidipine is a dihydropyridine calcium-channel blocker. It inhibits cellular influx of calcium, thus causing vasodilatation. It has greater selectivity for vascular smooth muscle. It has little or no action at the SA or AV nodes and -ve inotropic activity is rarely seen at therapeutic doses.
ATC Classification
 C08CA14 - cilnidipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Available As
  • Cilnidipine 10 mg
  • Cilnidipine 20 mg
  • Cilnidipine 5 mg

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