Chlorpropamide

Indications
 Oral
Type 2 diabetes mellitus
Adult: Initially, 250 mg daily as a single dose in the morning. Subsequent doses may be changed by 50-125 mg at intervals of 3-5 days. Maintenance: 100-500 mg daily. Max dose: 750 mg daily.
Max Dosage:
Oral
Cranial diabetes insipidus
Adult: Initially, 100 mg daily increased if necessary. Max dose: 350-500 mg daily.
Contraindications
 Type 1 DM, ketoacidosis, diabetic coma, severe infections or trauma. Renal, thyroid or hepatic impairment, porphyria.
Warnings / Precautions
 May cause intolerance to alcohol; higher risk of hypoglycemia in patients who are malnourished, elderly, patients with adrenal or pituitary insufficiency, taking more than one glucose-lowering drug, on β-adrenergic blockers or after prolonged period of exercise. Pregnancy and lactation.
Adverse Reactions
 GI disturbances; hypoglycaemia; cholestatic jaundice; agranulocytosis, lymphocytosis, thrombocytopenia, aplastic anaemia, haemolytic anaemia; nausea, vomiting, epigastric pain; weakness, paraesthesia, headache and sensitivity reactions, syndrome of inappropriate anti-diuretic hormone secretion.
Potentially Fatal: Hypoglycaemia especially in elderly with renal or hepatic disease.
Overdose Reactions
 Symptoms include hypoglycaemia. Mild hypoglycaemic symptoms without loss of consciousness or neurologic findings may be treated with oral glucose and adjustments in drug dosage and/or meal patterns.
Drug Interactions
 Abrupt withdrawal of phenobarbital or rifampicin may result in hypoglycaemia. Clofibrate potentiates chlorpropamide action. Probenecid decreases excretion. Alcohol impairs recovery from chlorpropamide-induced hypoglycaemia. Facial flushing with alcohol ingestion.
Potentially Fatal: Phenylbutazone, large doses of salicylates and coumarins potentiate the action of chlorpropamide. Chloramphenicol, in large doses, reduces urinary excretion. Thiazide diuretics reduce insulin release. Phenytoin and verapamil also reduce insulin release. Corticosteroids are potent antagonists of insulin and lead to marked deterioration in glucose tolerance. Oral contraceptives also antagonise insulin action. β-blockers lead to mild deterioration in glucose tolerance.
See Below for More chlorpropamide Drug Interactions
Food Interactions
 Absorption delayed but bioavailability not affected.
Mechanism of Actions
 Chlorpropamide stimulates the secretion of endogenous insulin from β-cells of the pancreas. It also exhibits antidiuretic activity by enhancing vasopressin in the renal tubules.
Duration: 24 hr.
Absorption: Readily absorbed from the GI tract (oral).
Distribution: Crosses the placenta; enters breast milk. Protein-binding: Extensive.
Metabolism: Hepatic (80%).
Excretion: Urine (as metabolites and unchanged drug); 35 hr (elimination half-life).
Administration
 Should be taken with food.
ATC Classification
 A10BB02 - chlorpropamide ; Belongs to the class of sulfonamides, urea derivatives. Used in the treatment of diabetes.
Available As
  • Chlorpropamide 100 mg
  • Chlorpropamide 250 mg
  • Chlorpropamide 50 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Chlorpropamide


    Chlorpropamide Containing Brands

    We are Developing Our database, More results coming soon.

    Chlorpropamide is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Chlorpropamide

    We are Developing Our database, More results coming soon.